| Gene Symbol |
TCF7L2
|
| Entrez Gene |
6934
|
| Alt Symbol |
TCF-4, TCF4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 7-like 2 (T-cell specific, HMG-box)
|
| Other Description |
HMG box transcription factor 4|T-cell factor 4|T-cell factor-4 variant A|T-cell factor-4 variant B|T-cell factor-4 variant C|T-cell factor-4 variant D|T-cell factor-4 variant E|T-cell factor-4 variant F|T-cell factor-4 variant G|T-cell factor-4 variant H|T-cell factor-4 variant I|T-cell factor-4 variant J|T-cell factor-4 variant K|T-cell factor-4 variant L|T-cell factor-4 variant M|T-cell factor-4 variant X2|T-cell-specific transcription factor 4|hTCF-4|transcription factor 7-like 2
|
| Swissprots |
O00185 E2GH24 B9X074 E2GH19 Q9NQB6 Q9NQB5 E2GH20 Q9NQB3 Q9ULC2 F8W7T5 E2GH14 Q9NQB2 E2GH25 C6ZRK0 Q9NQB1 F8W742 B4DRJ8 C6ZRJ8 Q9NQB0 Q9NQB7 Q9NQB4 E9PFH9
|
| Accessions |
AAQ08860 CAB97212 CAB97213 CAB97214 CAB97215 CAB97216 CAB97217 CAB97218 CAB97219 EAW49506 EAW49507 EAW49508 EAW49509 EAW49510 EAW49511 EAW49512 EAW49513 EAW49514 EAW49515 EAW49516 EAW49517 Q9NQB0 AB034691 BAA86225 AB440195 BAH24004 AB451266 BAG70080 AK074705 BAG51988 AK225809 AK296305 BAG59004 AK299295 BAG61310 AK301483 BAG62997 AK303684 BAG64677 AK315243 AK316111 BAH14482 BC032656 AAH32656 BX648364 CR536574 CAG38811 DA473655 FJ010164 ACI28522 FJ010165 ACI28523 FJ010166 ACI28524 FJ010167 ACI28525 FJ010168 ACI28526 FJ010169 ACI28527 FJ010170 ACI28528 FJ010171 ACI28529 FJ010172 ACI28530 FJ010173 ACI28531 FJ010174 ACI28532 HM352838 ADK35174 HM352839 ADK35175 HM352840 ADK35176 HM352841 ADK35177 HM352842 ADK35178 HM352843 ADK35179 HM352844 ADK35180 HM352845 ADK35187 HM352846 ADK35181 HM352847 ADK35182 HM352848 ADK35183 HM352849 ADK35184 HM352850 ADK35185 HM352851 ADK35186 Y11306 CAA72166 XM_005270071 XP_005270128 XM_005270073 XP_005270130 XM_005270074 XP_005270131 XM_005270075 XP_005270132 XM_005270077 XP_005270134 XM_005270078 XP_005270135 XM_005270079 XP_005270136 XM_005270080 XP_005270137 XM_005270082 XP_005270139 XM_005270083 XP_005270140 XM_005270084 XP_005270141 XM_005270085 XP_005270142 XM_005270086 XP_005270143 XM_005270088 XP_005270145 XM_005270089 XP_005270146 XM_005270091 XP_005270148 XM_005270092 XP_005270149 XM_005270093 XP_005270150 XM_005270094 XP_005270151 XM_005270095 XP_005270152 XM_005270096 XP_005270153 XM_005270100 XP_005270157 XM_005270101 XP_005270158 XM_005270102 XP_005270159 XM_005270103 XP_005270160 XM_005270104 XP_005270161 XM_006717956 XP_006718019 XM_011540109 XP_011538411 XM_011540110 XP_011538412 XM_011540111 XP_011538413 XM_011540112 XP_011538414 XM_011540113 XP_011538415 XM_011540114 XP_011538416 XM_011540115 XP_011538417 XM_011540116 XP_011538418 XM_011540117 XP_011538419 XM_011540118 XP_011538420 XM_011540119 XP_011538421 NM_001146274 NP_001139746 NM_001146283 NP_001139755 NM_001146284 NP_001139756 NM_001146285 NP_001139757 NM_001146286 NP_001139758 NM_001198525 NP_001185454 NM_001198526 NP_001185455 NM_001198527 NP_001185456 NM_001198528 NP_001185457 NM_001198529 NP_001185458 NM_001198530 NP_001185459 NM_001198531 NP_001185460 NM_030756 NP_110383
|
| Function |
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.
|
| Subcellular Location |
Nucleus, PML body {ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9916915}. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
|
| Tissue Specificity |
Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. {ECO:0000269|PubMed:9916915}.
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| Top Pathways |
Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer
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