| Gene Symbol |
Nlgn2
|
| Entrez Gene |
117096
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
neuroligin 2
|
| Other Description |
neuroligin-2
|
| Swissprots |
Q62888
|
| Accessions |
EDM04903 Q62888 U41662 AAA97870 NM_053992 NP_446444
|
| Function |
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secreti
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at presynaptic membranes in retina, and at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes.
|
| Tissue Specificity |
Detected on hippocampus neurons, especially at inhibitory synapses. Detected in retina, in the outer and inner plexiform layer. Detected in pancreas, in islet of Langerhans beta cells (at protein level). Expressed in brain, spinal chord and dorsal root ganglion. Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:11329178, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19755106, ECO:0000269|PubMed:19859968, ECO:0000269|PubMed:19914352, ECO:0000269|PubMed:8576240}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|