MGAT5B

Gene Symbol MGAT5B
Entrez Gene 146664
Alt Symbol GnT-IX, GnT-VB
Species Human
Gene Type protein-coding
Description mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
Other Description N-acetylglucosaminyl-transferase Vb|N-acetylglucosaminyltransferase IX|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B|beta(1,6)-N-acetylglucosaminyltransferase V|glcNAc-T Vb|hGnTVb|mannoside acetylglucosaminyltransferase 5B|mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
Swissprots Q76D04 Q96LS2 Q766X5 Q6P3S8 Q6P6B3 Q3V5L5
Accessions EAW89457 EAW89458 EAW89459 EAW89460 Q3V5L5 AB109185 BAC84969 AB114297 BAD02406 AB235153 BAE44474 AK123189 AW191036 BC036948 BC041577 BC062354 AAH62354 BC063862 AAH63862 BC144361 BC156823 AAI56824 HG509473 HG509474 HG509475 XM_005257065 XP_005257122 XM_006721707 XP_006721770 XM_011524348 XP_011522650 XM_011524349 XP_011522651 XM_011524350 XP_011522652 XM_011524351 XP_011522653 XM_011524352 XP_011522654 XM_011524353 XP_011522655 XM_011524354 XP_011522656 XR_934377 NM_001199172 NP_001186101 NM_144677 NP_653278 NM_198955 NP_945193
Function Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14617637, ECO:0000269|PubMed:14623122, ECO:0000269|PubMed:16606368, ECO:0000269|PubMed:16857188}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14623122}.
Top Pathways N-Glycan biosynthesis, Other types of O-glycan biosynthesis

GnT-VB CRISPR/Cas9 KO Plasmid (h) - sc-414584 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB HDR Plasmid (h) - sc-414584-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB Double Nickase Plasmid (h) - sc-414584-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB Double Nickase Plasmid (h2) - sc-414584-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB CRISPR Activation Plasmid (h) - sc-414584-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB CRISPR Activation Plasmid (h2) - sc-414584-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB Lentiviral Activation Particles (h) - sc-414584-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB Lentiviral Activation Particles (h2) - sc-414584-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GnT-VB siRNA (h) - sc-94051 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GnT-VB shRNA Plasmid (h) - sc-94051-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GnT-VB shRNA (h) Lentiviral Particles - sc-94051-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU030631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13279 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13279 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09674 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09674

MGAT5B siRNA (Human) - CRJ5481 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Mgat5b (NM_144677.2) - SHH341423 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MGAT5B(NM_144677.2) - SHH187535 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MGAT5B(NM_198955.1) - SHH187553 from Creative biogene

Category siRNA
Species Reactivities Human

MGAT5B shRNA Plasmid (Human) - CHJ5481 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MGAT5B miRNA 3'UTR clone - MiUTR1H-06246 from Creative biogene

Species Reactivities Human

MGAT5B miRNA 3'UTR clone - MiUTR1H-06247 from Creative biogene

Species Reactivities Human
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