TREX1

Gene Symbol	TREX1
Entrez Gene	11277
Alt Symbol	AGS1, CRV, DRN3, HERNS
Species	Human
Gene Type	protein-coding
Description	three prime repair exonuclease 1
Other Description	3' repair exonuclease 1|3'-5' exonuclease TREX1|DNase III|deoxyribonuclease III|three-prime repair exonuclease 1
Swissprots	Q8TEU2 B2RCN9 Q9NSU2 Q9BPW1 Q9Y4X2
Accessions	AAL82504 CCQ43540 EAW64883 Q9NSU2 AF151105 AAD48774 AJ243797 CAB50866 AK315196 BAG37636 AL137745 BC019863 BC023630 AAH23630 BC160084 AAI60084 BQ933154 BT020052 AAV38855 BT020053 AAV38856 CR457119 CAG33400 DA364183 DA850044 EU832638 ACE87729 EU832715 ACE87047 NM_007248 NP_009179 NM_016381 NP_057465 NM_033629 NP_338599 NM_033627 NM_033628
Function	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:103919
Subcellular Location	Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. {ECO:0000250}.
Tissue Specificity	Detected in thymus, spleen, liver, brain, heart, small intestine and colon. {ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:11278605}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TREX1 full length protein - ab161394 from Abcam Category Protein Source Wheat germ Species Human

Human TREX1 protein fragment - ab161395 from Abcam Category Protein Source Wheat germ Species Human

TREX1 Antibody Blocking Peptide - LS-E30632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TREX1 Protein - H00011277-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TREX1 Recombinant Protein - H00011277-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TREX1 Blocking Peptide - NBP1-76977PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TREX1 - H00011277-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TREX1 - H00011277-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TREX1 - H00011277-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TREX1 - H00011277-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TREX1 Control Peptide - AP30942CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TREX1 Peptide - 4969P from ProSci Category Peptide Species Human

TREX1 fusion protein - ag18214 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TREX1 fusion protein - ag18325 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Three prime repair exonuclease 1(TREX1) - CSB-YP865133HU CSB-EP865133HU CSB-BP865133HU CSB-MP865133HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Three prime repair exonuclease 1 (TREX1), Recombinant Protein - MBS1332376 from MyBioSource Category Protein Prices $780.00, $895.00, $1,025.00, $1,045.00, $1,150.00, $1,200.00, $1,270.00, $1,300.00, $1,355.00, $1,635.00, $1,870.00, $1,925.00, $2,065.00, $2,485.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 500 µg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Three Prime Repair Exonuclease 1 (TREX1) - RPC810Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Three Prime Repair Exonuclease 1 (TREX1) - RPC810Hu01 from Cloud-clone Category Protein Source E.coli Species Human

TREX1 Recombinant Protein Antigen - NBP1-89202PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

TREX1 Peptide, Human - M34GP16554H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Three Prime Repair Exonuclease 1 (TREX1) - RPU52418 from Biomatik Category Protein Prices $187.00, $383.00, $586.00, $698.64 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

TREX1 Recombinant Protein (OPCD00623) - OPCD00623 from Aviva Systems Biology Category Protein Source E.coli Species Human

ATRIP Recombinant Protein Antigen - NBP2-55702PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Three prime repair exonuclease 1 (TREX1), Recombinant Protein - MBS7053496 from MyBioSource Category Protein Prices $640.00, $785.00, $865.00, $930.00, $950.00, $1,055.00, $1,170.00, $1,175.00, $1,190.00, $1,340.00, $1,695.00, $1,780.00, $1,810.00, $2,260.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human TREX1 Protein (1-369 aa), His-MBP-tagged - TREX1-2756H from Creative Biomart Category Protein Source Baculovirus Species Human

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