SGPP2

Gene Symbol SGPP2
Entrez Gene 130367
Alt Symbol SPP2
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate phosphatase 2
Other Description SPPase2|hSPP2|sphingosine 1-phosphate phosphohydrolase 2|sphingosine-1-phosphatase 2|sphingosine-1-phosphate phosphotase 2
Swissprots Q8IWX5 Q8N8Q6 A3KPB4
Accessions AAX88957 AAY24195 EAW70801 Q8IWX5 AF542512 AAN28731 AK096323 BAC04762 AK314322 BAG36970 BC106904 AAI06905 BC106905 AAI06906 BC114513 BC134342 AAI34343 XM_005246297 XP_005246354 NM_152386 NP_689599
Function Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:17113265}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269|PubMed:12411432}.
Tissue Specificity Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269|PubMed:12411432}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SPPase2 CRISPR/Cas9 KO Plasmid (h) - sc-407867 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 HDR Plasmid (h) - sc-407867-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 Double Nickase Plasmid (h) - sc-407867-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 Double Nickase Plasmid (h2) - sc-407867-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 CRISPR Activation Plasmid (h) - sc-407867-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 CRISPR Activation Plasmid (h2) - sc-407867-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 Lentiviral Activation Particles (h) - sc-407867-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 Lentiviral Activation Particles (h2) - sc-407867-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPPase2 siRNA (h) - sc-63062 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPPase2 shRNA Plasmid (h) - sc-63062-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPPase2 shRNA (h) Lentiviral Particles - sc-63062-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU018961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0858 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0856 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0857 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN19237 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19237 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SGPP2 siRNA (Human) - CRJ5028 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SGPP2 - MBS8212474 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SGPP2 (NM_152386.2) - SHH406376 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SGPP2(NM_152386.2) - SHR221996 from Creative biogene

Category siRNA
Species Reactivities Human

SGPP2 shRNA Plasmid (Human) - CHJ5028 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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