| Gene Symbol | CD302 |
|---|---|
| Entrez Gene | 9936 |
| Alt Symbol | BIMLEC, CLEC13A, DCL-1, DCL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD302 molecule |
| Other Description | C-type lectin domain family 13, member A|CD302 antigen|DEC205-associated C-type lectin 1|type I transmembrane C-type lectin receptor DCL-1 |
| Swissprots | Q8IX05 A8K5G4 B4E2T9 Q15009 |
| Accessions | AAY14942 EAX11399 Q8IX05 AF499000 AAN77050 AK125081 AK291279 BAF83968 AK304422 BAG65251 AY314007 AAP79900 BC020646 AAH20646 CB240843 D14664 BAA03498 DB217404 DB460994 NM_001198763 NP_001185692 NM_001198764 NP_001185693 NM_014880 NP_055695 |
| Function | Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. {ECO:0000269|PubMed:17947679}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269|PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269|PubMed:17947679}. Cell projection, microvillus {ECO:0000269|PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface. |
| Tissue Specificity | Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed- Sternberg (HRS) cells. {ECO:0000269|PubMed:12824192, ECO:0000269|PubMed:17947679}. |