DAPK1

Gene Symbol	DAPK1
Entrez Gene	1612
Alt Symbol	DAPK
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 1
Other Description	DAP kinase 1
Swissprots	Q1W5W0 Q6ZRZ3 P53355 B7ZLE7 Q9BTL8 Q68CP8 Q14CQ7 B7ZLD2
Accessions	ABD96827 EAW62725 EAW62726 EAW62727 EAW62728 P53355 AA846231 AA854055 AB208871 BAD92108 AK127855 BAC87163 AK295119 BAG58146 AK296839 BAH12440 BC113660 AAI13661 BC143730 BC143733 AAI43734 BC143759 AAI43760 BG110813 BP202018 BT006935 AAP35581 CD642694 CN347006 CR749834 CAH18690 CX758421 CX872304 DA234399 DA855348 DA887235 DC340223 DR002874 EF090258 ABK78671 H77515 HQ258533 ADR83287 X76104 CAA53712 XM_005251757 XP_005251814 NM_001288729 NP_001275658 NM_001288730 NP_001275659 NM_001288731 NP_001275660 NM_004938 NP_004929
Function	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pa
Subcellular Location	Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.
Tissue Specificity	Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DAP Kinase 1 protein fragment - ab63191 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human DAP Kinase 1 full length protein - ab132039 from Abcam Category Protein Source Wheat germ Species Human

Human DAP Kinase 1 protein fragment - ab152326 from Abcam Category Protein Source Wheat germ Species Human

DAPK1 / DAP Kinase Antibody Blocking Peptide - LS-E4119 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK1 / DAP Kinase Antibody Blocking Peptide - LS-E8773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK1 / DAP Kinase Antibody Blocking Peptide - LS-E21302 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DAP Kinase 1 Protein - H00001612-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DAP Kinase 1 Protein - H00001612-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DAP Kinase 1 Recombinant Protein - P4674 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

DAP Kinase 1 Peptide - P2385 from Novus Biologicals Category Peptide Species Human

DAPK1-Antibody-C-term-Blocking-Peptide - BP7217b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DAP Kinase 2 peptide - GTX28436 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

DAPK1 peptide - orb72600 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

DAPK1 Blocking Peptide - 33R-6570 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DAPK1 - H00001612-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAPK1 - H00001612-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAPK1 - H00001612-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAPK1 - H00001612-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAPK1 - P4674 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

DAPK1 - P5696 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

DAPK1 fusion protein - ag18006 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DAPK1 fusion protein - Ag18387 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DAPK1 Active Human Recombinant Protein - GWB-C2E2A4 from Genway Biotech Category Protein Prices $479.00 Sizes 10 µg Species Human

Recombinant Human DAPK1, GST-tagged, Active - DAPK1-289H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human DAPK1, His & GST tagged - DAPK1-971H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

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