| Gene Symbol | DAPK1 |
|---|---|
| Entrez Gene | 1612 |
| Alt Symbol | DAPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | death-associated protein kinase 1 |
| Other Description | DAP kinase 1 |
| Swissprots | Q1W5W0 Q6ZRZ3 P53355 B7ZLE7 Q9BTL8 Q68CP8 Q14CQ7 B7ZLD2 |
| Accessions | ABD96827 EAW62725 EAW62726 EAW62727 EAW62728 P53355 AA846231 AA854055 AB208871 BAD92108 AK127855 BAC87163 AK295119 BAG58146 AK296839 BAH12440 BC113660 AAI13661 BC143730 BC143733 AAI43734 BC143759 AAI43760 BG110813 BP202018 BT006935 AAP35581 CD642694 CN347006 CR749834 CAH18690 CX758421 CX872304 DA234399 DA855348 DA887235 DC340223 DR002874 EF090258 ABK78671 H77515 HQ258533 ADR83287 X76104 CAA53712 XM_005251757 XP_005251814 NM_001288729 NP_001275658 NM_001288730 NP_001275659 NM_001288731 NP_001275660 NM_004938 NP_004929 |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pa |
| Subcellular Location | Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers. |
| Tissue Specificity | Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}. |
| Top Pathways | Bladder cancer |