OTULIN

Gene Symbol	OTULIN
Entrez Gene	90268
Alt Symbol	FAM105B, GUM
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase with linear linkage specificity
Other Description	OTU domain-containing deubiquitinase with linear linkage specificity|deubiquitinating enzyme otulin|family with sequence similarity 105, member B|gumby|protein FAM105B|ubiquitin thioesterase Gumby|ubiquitin thioesterase otulin
Swissprots	Q96BN8 D3DTD3 Q96IA3 Q8NAS0
Accessions	EAX08037 EAX08038 EAX08039 Q96BN8 AK092203 BAC03828 AK095615 AK123480 BC007706 AAH07706 BC015392 AAH15392 CK817982 XM_011514151 XP_011512453 XM_011514152 XP_011512454 XM_011514153 XP_011512455 XM_011514154 XP_011512456 NM_138348 NP_612357
Function	Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23746843}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OTULIN Antibody - 14127 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

FAM105B (F-14) - sc-162789 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-FAM105B antibody - ab151117 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FAM105B antibody - ab114137 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FAM105B antibody - C-terminal - ab182598 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, AP) - LS-C256975 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, APC) - LS-C256974 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, FITC) - LS-C256976 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, Azide-free, HRP) - LS-C256978 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, PE) - LS-C256981 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128, Biotin) - LS-C256977 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa106-137) - LS-C321265 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa238-287) - LS-C201793 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-OTULIN / FAM105B Antibody (aa99-128) - LS-C165928 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

FAM105B/OTULIN Antibody - NBP2-14722 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-FAM105B (CENTER) antibody produced in rabbit - SAB1301125 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FAM105B antibody produced in rabbit - HPA051074 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FAM105B Antibody - C-terminal region (ARP70290_P050) - ARP70290_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FAM105B Antibody - middle region (OAAB03142) - OAAB03142 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

FAM105B-Antibody-Center - AP5734c from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Anti -FAM105B, ID (FAM105B, Protein FAM105B) - 035354 from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -FAM105B, ID (FAM105B, Protein FAM105B) (AP) - 035354-AP from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -FAM105B, ID (FAM105B, Protein FAM105B) (APC) - 035354-APC from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -FAM105B, ID (FAM105B, Protein FAM105B) (Azide free) (HRP) - 035354-HRP from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -FAM105B, ID (FAM105B, Protein FAM105B) (Biotin) - 035354-Biotin from USBiological Life Science Host Rabbit Clonality Polyclonal

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