TSPYL2

Gene Symbol TSPYL2
Entrez Gene 64061
Alt Symbol CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX
Species Human
Gene Type protein-coding
Description TSPY-like 2
Other Description CASK-interacting nucleosome assembly protein|CTCL tumor antigen se20-4|CTCL-associated antigen se20-4|TSPY-like protein 2|cell division autoantigen 1|cutaneous T-cell lymphoma-associated antigen se20-4|cutaneous T-cell lymphoma-associated tumor antigen se20-4|differentially expressed nucleolar TGF-beta1 target|differentially-expressed nucleolar TGF-beta1 target protein|nuclear protein of 79 kDa|testis-specific Y-encoded-like protein 2|testis-specific protein Y encoded-like 2
Swissprots Q9H2G4 O94799 Q9BZW6 Q96DG7
Accessions EAW93143 EAW93144 Q9H2G4 AB015345 BAA34802 AB209182 BAD92419 AF254794 AAG53596 AF273046 AAG34906 AI208075 AK131220 BAG54754 AK292462 BAF85151 AL713652 CAD28461 AM392716 CAL37594 AY040871 AAK72407 BC001566 AAH01566 BC024270 AAH24270 DA076199 XM_006724592 XP_006724655 NM_022117 NP_071400
Function Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:12393179, ECO:0000269|PubMed:15241014}.

Anti-CINAP antibody - ab10318 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DENTT antibody - ab168860 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DENTT antibody (ab168860) at 0.4 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-DENTT antibody - ab126290 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab126290, at 5 ug/ml, staining DENTT in paraffin-embedded Human testis tissue by Immunohistochemistry.

Anti-DENTT antibody - ab130137 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-DENTT antibody - ab180096 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DENTT antibody (ab180096) at 1/1000 dilution + MCF7 cell line lysates at 35 µg

Anti-DENTT antibody - ab130148 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-DENTT antibody (ab130148) at 0.3 µg/ml + Jurkat cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-DENTT antibody - ab93383 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DENTT antibody - ab81757 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TSPYL2 / DENTT Antibody - LS-C40684 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TSPYL2 / DENTT Antibody - LS-C83755 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TSPYL2 / DENTT Antibody (aa2-13) - LS-C154949 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TSPYL2 / DENTT Antibody (aa680-693) IHC-plus™ - LS-B5906 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TSPYL2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5906 concentration 5 ug/ml.

Anti-TSPYL2 / DENTT Antibody (aa1-50) - LS-C290657 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DENTT by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-DENTT antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-TSPYL2 / DENTT Antibody (aa643-693) - LS-C290658 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DENTT by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat cells. Antibodies: Affinity purified rabbit anti-DENTT antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-TSPYL2 / DENTT Antibody (aa380-409) - LS-C204009 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TSPYL2 Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The TSPYL2 antibody detected the TSPYL2 protein (arrow).

Anti-TSPYL2 / DENTT Antibody (aa441-454) IHC-plus™ - LS-B11181 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TSPYL2 / DENTT antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11181 concentration 5 ug/ml.

CINAP Antibody - NBP1-52123 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: CINAP Antibody [NBP1-52123] (5ug/ml) staining of paraffin embedded Human Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

DENTT Polyclonal Antibody - bs-7051R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti DENTT Polyclonal Antibody, Unconjugated (bs-7051R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-TSPYL2 antibody produced in goat - SAB2502020 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TSPYL2<B>Cat. No. SAB2502020</B>: Immunoblotting (0.3 μg/mL) staining of Jurkat lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TSPYL2 (516-530) antibody produced in rabbit - T4078 from Sigma-Aldrich

Prices $342.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-TSPYL2 (516-530): <B>Cat. No. T4078</B>: Immunofluorescence of HUVEC cells using TSPYL2 (516-530) (RB),<B>Cat. No. T4078</B> (red) at a 1:200 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-TSPYL2 antibody produced in rabbit - HPA044133 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TSPYL2: <B>Cat. No. HPA044133</B>: Immunohistochemical staining of human stomach shows membranous positivity in glandular cells.

Anti-TSPYL2 (C-terminal) antibody produced in goat - SAB2501801 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

TSPYL2-Antibody-Center - AP20456c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
TSPYL2 Antibody (Center) (Cat. #AP20456c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the TSPYL2 antibody detected the TSPYL2 protein (arrow).

DENTT--CDA1-Antibody-C-Term - AF2250a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2250a (5 µg/ml) staining of paraffin embedded Human Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

TSPYL2-aa441-454-Antibody-internal-region - AF3688a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3688a (0.3 µg/ml) staining of Jurkat lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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