| Gene Symbol |
Trpa1
|
| Entrez Gene |
277328
|
| Alt Symbol |
Anktm1, TRPA1b
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily A, member 1
|
| Other Description |
ANKTM1|ankyrin-like with transmembrane domains protein 1|transient receptor potential cation channel subfamily A member 1
|
| Swissprots |
Q8BLA8 Q0VBN5
|
| Accessions |
EDL14331 EDL14332 Q8BLA8 AK045771 BAC32487 AY231177 AAO43183 BC120563 AAI20564 BC131963 AAI31964 KF460461 AHB62275 XM_006495526 XP_006495589 XM_011238386 XP_011236688 NM_177781 NP_808449
|
| Function |
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. {ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15046718, ECO:0000269|PubMed:15483558, ECO:0000269|PubMed:15843607}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in inner ear (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion. {ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15194861, ECO:0000269|PubMed:15483558, ECO:0000269|PubMed:15843607}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|