DERL2

Gene Symbol DERL2
Entrez Gene 51009
Alt Symbol CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa
Species Human
Gene Type protein-coding
Description derlin 2
Other Description Der1-like domain family, member 2|carcinoma related|degradation in endoplasmic reticulum protein 2|derlin-2
Swissprots Q9GZP9 Q9Y3A7
Accessions EAW90329 Q9GZP9 AF132289 AAG43049 AF151859 AAD34096 AF208065 AAL14869 AF242523 AAF99603 AK024574 AK092218 BC010890 AAH10890 BG110482 BM675359 BU199049 CA425310 CN362881 CN362882 CR457202 CAG33483 HQ448209 ADQ32689 HY051246 XM_006721539 XP_006721602 XM_011523914 XP_011522216 XM_011523915 XP_011522217 XR_934033 XR_934034 NM_001304777 NP_001291706 NM_001304779 NP_001291708 NM_016041 NP_057125 NR_130905 NR_130906
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Tissue Specificity Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}.
Top Pathways Protein processing in endoplasmic reticulum

Derlin-2 CRISPR/Cas9 KO Plasmid (h) - sc-408875 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 HDR Plasmid (h) - sc-408875-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 Double Nickase Plasmid (h) - sc-408875-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 Double Nickase Plasmid (h2) - sc-408875-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 CRISPR Activation Plasmid (h) - sc-408875-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 CRISPR Activation Plasmid (h2) - sc-408875-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 Lentiviral Activation Particles (h) - sc-408875-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 Lentiviral Activation Particles (h2) - sc-408875-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-2 siRNA (h) - sc-60521 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Derlin-2 shRNA Plasmid (h) - sc-60521-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Derlin-2 shRNA (h) Lentiviral Particles - sc-60521-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU096911 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7156 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7156 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03528 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03528

DERL2 siRNA (Human) - CRH9450 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DERL2 - MBS8233619 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DERL2(NM_016041.3) - SHH001919 from Creative biogene

Category siRNA
Species Reactivities Human

Human DERL2 siRNA - orb269952 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DERL2 shRNA Plasmid (Human) - CHH9450 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DERL2 miRNA 3'UTR clone - MiUTR1H-02784 from Creative biogene

Species Reactivities Human
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