Gene Symbol | Dpm2 |
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Entrez Gene | 13481 |
Alt Symbol | AW557993, R75484 |
Species | Mouse |
Gene Type | protein-coding |
Description | dolichol-phosphate (beta-D) mannosyltransferase 2 |
Other Description | DPM synthase subunit 2|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol-phosphate mannose synthase subunit 2 |
Swissprots | Q9Z324 |
Accessions | EDL08553 Q9Z324 AB013360 BAA33973 AK002468 BAB22122 AK004241 BAB23234 AK086634 AK179411 BC008256 AAH08256 NM_010073 NP_034203 |
Function | Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Top Pathways | N-Glycan biosynthesis, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
DPM2 CRISPR/Cas9 KO Plasmid (m) - sc-420047 from Santa Cruz Biotechnology
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DPM2 HDR Plasmid (m) - sc-420047-HDR from Santa Cruz Biotechnology
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DPM2 Double Nickase Plasmid (m) - sc-420047-NIC from Santa Cruz Biotechnology
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DPM2 Double Nickase Plasmid (m2) - sc-420047-NIC-2 from Santa Cruz Biotechnology
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DPM2 CRISPR Activation Plasmid (m) - sc-420047-ACT from Santa Cruz Biotechnology
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DPM2 CRISPR Activation Plasmid (m2) - sc-420047-ACT-2 from Santa Cruz Biotechnology
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DPM2 Lentiviral Activation Particles (m) - sc-420047-LAC from Santa Cruz Biotechnology
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DPM2 Lentiviral Activation Particles (m2) - sc-420047-LAC-2 from Santa Cruz Biotechnology
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DPM2 siRNA (m) - sc-41512 from Santa Cruz Biotechnology
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DPM2 shRNA Plasmid (m) - sc-41512-SH from Santa Cruz Biotechnology
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DPM2 shRNA (m) Lentiviral Particles - sc-41512-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU048831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30199 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30199 from Sigma-Aldrich
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DPM2 siRNA (Mouse) - CRM1073 from Cohesion Biosciences
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DPM2 - MBS8240992 from MyBioSource
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shRNA set against Mouse DPM2 (NM_010073.2) - SHH280621 from Creative biogene
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shRNA set against Mouse Dpm2(NM_010073.2) - SHH014249 from Creative biogene
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Mouse DPM2 siRNA - orb280549 from Biorbyt
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DPM2 shRNA Plasmid (Mouse) - CHM1073 from Cohesion Biosciences
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