Gene Symbol | SIPA1 |
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Entrez Gene | 6494 |
Alt Symbol | SPA1 |
Species | Human |
Gene Type | protein-coding |
Description | signal-induced proliferation-associated 1 |
Other Description | GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1|sipa-1 |
Swissprots | O60618 Q96FS4 O60484 O14518 Q2YD83 |
Accessions | AAC32559 EAW74421 EAW74422 EAW74423 Q96FS4 AB005666 BAA22197 AF029789 AAC32547 AI307277 AK303551 BAG64575 AK308234 AK310068 BC010492 AAH10492 BC110353 AAI10354 BM677738 DN999403 XM_005274189 XP_005274246 XM_011545214 XP_011543516 XM_011545215 XP_011543517 XR_247210 XR_950017 NM_006747 NP_006738 NM_153253 NP_694985 |
Function | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:9346962}. |
Subcellular Location | Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. |
Tissue Specificity | Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. |
Top Pathways | Leukocyte transendothelial migration, Rap1 signaling pathway |
Human SIPA1 peptide - ab23193 from Abcam
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Human SIPA1 protein fragment - ab159512 from Abcam
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SIPA1 Antibody Blocking Peptide - LS-E4628 from LifeSpan Bioscience
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SIPA1 Antibody Blocking Peptide - LS-E25674 from LifeSpan Bioscience
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SIPA1 Antibody Blocking Peptide - LS-E21512 from LifeSpan Bioscience
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SIPA1 Antibody Blocking Peptide - LS-E31216 from LifeSpan Bioscience
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Recombinant Human SIPA1 Protein - H00006494-Q01 from Novus Biologicals
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SIPA1-Antibody-C-term-Blocking-Peptide - BP16989b from Abgent, a WuXi AppTec company
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SIPA1 blocking peptide - GTX10162-PEP from GeneTex
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SIPA1 Blocking Peptide - 33R-8976 from Fitzgerald
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SIPA1 Peptide - AC21-0504-P from Abcore
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SIPA1 / SPA1 - H00006494-Q01-10 from Acris Antibodies
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SIPA1 / SPA1 - H00006494-Q01-25 from Acris Antibodies
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SIPA1 / SPA1 (N-term) Control Peptide - AP55608CP-N from Acris Antibodies
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SIPA1 Peptide - 46-371P from ProSci
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SIPA1 Peptide - 6643P from ProSci
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SIPA1 fusion protein - ag17874 from Proteintech Group
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SIPA1 fusion protein - ag3383 from Proteintech Group
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Recombinant Human Signal-induced proliferation-associated protein 1(SIPA1) ,part - CSB-YP822213HU CSB-EP822213HU CSB-BP822213HU CSB-MP822213HU from Cusabio
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SPA1/SIPA1, Peptide - MBS425748 from MyBioSource
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SIPA1 Protein - NBP2-32620PEP from Novus Biologicals
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SIPA1 fusion protein - Ag25383 from Proteintech Group
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SIPA1 Peptide, Human - M34GP14258H from Creative Peptides
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Signal-induced proliferation-associated protein 1 (SIPA1), partial, Recombinant Protein - MBS1485144 from MyBioSource
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