FER

Gene Symbol FER
Entrez Gene 2241
Alt Symbol PPP1R74, TYK3, p94-Fer
Species Human
Gene Type protein-coding
Description fer (fps/fes related) tyrosine kinase
Other Description feline encephalitis virus-related kinase FER|fujinami poultry sarcoma/Feline sarcoma-related protein Fer|phosphoprotein NCP94|protein phosphatase 1, regulatory subunit 74|proto-oncogene c-Fer|tyrosine kinase 3|tyrosine-protein kinase Fer
Swissprots H2FLB8 B4DSQ2 P16591 B2RCR4
Accessions EAW49054 EAW49055 EAW49056 P16591 AK021888 AK092320 AK123847 AK293376 BAG56888 AK296874 BAG59436 AK299855 BAG61714 AK315234 BAG37661 AL707447 BC017060 AAH17060 BC058030 AAH58030 BC141559 AAI41560 BQ009328 BU155168 J03358 AAA61190 JQ412173 AEY69041 XM_011543266 XP_011541568 XM_011543267 XP_011541569 XM_011543268 XP_011541570 XM_011543269 XP_011541571 XM_011543270 XP_011541572 XM_011543271 XP_011541573 XM_011543272 XP_011541574 XM_011543273 XP_011541575 XM_011543274 XP_011541576 XM_011543275 XP_011541577 XM_011543276 XP_011541578 XM_011543277 XP_011541579 XM_011543278 XP_011541580 XR_948244 XR_948245 NM_001308028 NP_001294957 NM_001308031 NP_001294960 NM_001308038 NP_001294967 NM_005246 NP_005237
Function Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-ne
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts.
Tissue Specificity Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. {ECO:0000269|PubMed:18985748, ECO:0000269|PubMed:2156206, ECO:0000269|PubMed:22223638}.
Top Pathways Adherens junction

Fer (5D2) Mouse mAb - 4268 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 5D2
Western blot analysis of extracts from NIH/3T3, A549 and SK-MEL-5 cells using Fer (5D2) Mouse mAb.

Fer (C-1) - sc-390484 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fer (C-1): sc-390484. Western blot analysis of Fer expression in Jurkat whole cell lysate.

Fer (H-180) - sc-28771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fer (H-180): sc-28771. Western blot analysis of Fer expression in Jurkat whole cell lysate.

Fer (5D2C4) - sc-81708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fer (5D2C4): sc-81708. Western blot analysis of Fer expression in Jurkat whole cell lysate.

Fer (K-15) - sc-30707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Fer (N-14) - sc-14310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fer (N-14): sc-14310. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

Fer (P-17) - sc-30706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fer (P-17): sc-30706. Western blot analysis of Fer expression in non-transfected: sc-117752 (A) and human Fer transfected: sc-128617 (B) 293T whole cell lysates.

Fer (6B9) - sc-81461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Fer (6B9): sc-81461. Western blot analysis of Fer expression in pervanadate treated A-431 (A), SW480 (B), SW620 (C), HT29 (D), MCF7 (E), MDA-MB-231 (F) and T-47D (G) whole cell lysates.

Fer (2358C3a) - sc-81272 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Fer (2358C3a): sc-81272 Western Blot analysis of human recombinant Fer fusion protein.

Anti-FER (phospho Y402) antibody - ab79573 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab79573, at a 1/50 dilution, staining FER in paraffin embedded human brain tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunizing peptide.

Anti-FER antibody - ab79358 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FER antibody (ab79358) at 1/500 dilutionLane 1 : extracts from HeLa cells, treated with paclitaxel (1 µM, 24 hours) Lane 2 : extracts from HeLa cells, treated with paclitaxel (1 µM, 24 hours) with immunizing peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-FER antibody - ab65053 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FER antibody (ab65053) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-FER antibody [2358C3a] - ab53754 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2358C3a
Anti-FER antibody [2358C3a] (ab53754) + recombinant immunising proteindeveloped using the ECL technique

Anti-FER antibody [5D2C4] - ab130199 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D2C4
All lanes : Anti-FER antibody [5D2C4] (ab130199) at 1/500 dilutionLane 1 : NIH 3T3 cell lysateLane 2 : A549 cell lysateLane 3 : SK-MEL-5 cell lysate

Anti-FER antibody [EP1842Y] - ab52479 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1842Y
Anti-FER antibody [EP1842Y] (ab52479) at 1/5000 dilution + Jurkat cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-FER antibody - C-terminal - ab71682 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FER antibody - C-terminal (ab71682) at 1/100 dilution + HL-60 cell lysate at 12.5 µg

Anti-FER Antibody (aa521-536) - LS-C313021 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
FER antibody. IHC(P): Rat Intestine Tissue.

Anti-FER Antibody (clone 5D2C4) IHC-plus™ - LS-B3467 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 5D2C4
Anti-FER antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3467 dilution 1:200.

Anti-FER Antibody (aa797-811) - LS-C6775 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-FER Antibody - LS-C65986 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-FER Antibody (aa809-822) - LS-C128988 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FER Antibody (Internal, Biotin) - LS-C142719 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FER Antibody (Internal, DY488) - LS-C142721 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FER Antibody (Internal, HRP) - LS-C142722 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FER Antibody (aa400-450, DY550) - LS-C142723 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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