| Gene Symbol |
wts
|
| Entrez Gene |
43651
|
| Alt Symbol |
CG12072, Dlats, Dmel\CG12072, LATS, LATS1, Lats, Lats/Warts, MENE (3R)-G, WTS/LATS, Warts, Warts/Lats, Wts, Wts/Lats, dmLATS, l(3)100Aa, lats, lts, wart, warts/lats, wts/lats
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
warts
|
| Other Description |
CG12072-PA|Warts/Lats|large tumor suppressor|large tumor supressor|miracle-gro|warts kinase|warts/D-lats|warts/large tumour suppressor|wts-PA
|
| Swissprots |
Q9VA38
|
| Accessions |
AAF57085 Q9VA38 NM_170524 NP_733403
|
| Function |
Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd- independent, mechanism. {ECO:0000269|PubMed:16096061, ECO:0000269|PubMed:18256197, ECO:0000269|PubMed:18818081}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18245354}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18245354}. Note=Colocalizes with mats and cyclin E at the centrosome.
|
| Top Pathways |
Hippo signaling pathway - fly
|