| Gene Symbol |
CYBA
|
| Entrez Gene |
1535
|
| Alt Symbol |
p22-PHOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome b-245, alpha polypeptide
|
| Other Description |
cytochrome b light chain|cytochrome b(558) alpha chain|cytochrome b(558) alpha-subunit|cytochrome b, alpha polypeptide|cytochrome b-245 light chain|cytochrome b558 subunit alpha|flavocytochrome b-558 alpha polypeptide|neutrophil cytochrome b 22 kDa polypeptide|p22 phagocyte B-cytochrome|p22phox|superoxide-generating NADPH oxidase light chain subunit
|
| Swissprots |
P13498 Q9BR72 Q14090
|
| Accessions |
AAM96953 ABF20535 EAW66793 EAW66794 EAW66795 EAW66796 P13498 AK097127 AK125578 AK300049 BAG61858 AK309030 BC006465 AAH06465 BC011565 BC028224 BC033739 BT006861 AAP35507 BX109994 DQ893235 ABM84161 DQ896565 ABM87564 M21186 AAA90925 XM_011522905 XP_011521207 NM_000101 NP_000092
|
| Function |
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15585859, ECO:0000269|PubMed:22808130}.
|
| Top Pathways |
Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation
|
![Western Blot: Cytochrome b245 alpha Overexpression Lysate (Adult Normal) [NBL1-09657] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cytochrome b245 alpha.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2924_Cytochrome%2520b245%2520alpha%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09657-img0002.jpg)