Gene Symbol |
PRCP
|
Entrez Gene |
5547
|
Alt Symbol |
HUMPCP, PCP
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
prolylcarboxypeptidase (angiotensinase C)
|
Other Description |
angiotensinase C|lysosomal Pro-X carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein
|
Swissprots |
B3KRK5 P42785 B2R7B7 A8MU24 B5BU34
|
Accessions |
EAW75074 EAW75075 EAW75076 P42785 AB451270 BAG70084 AB451397 BAG70211 AK090847 BAG52238 AK091786 BAG52417 AK302386 BAH13692 AK312919 BAG35764 BC001500 AAH01500 BI827978 BX537480 DB461615 DQ893068 ABM83994 DQ896321 ABM87320 L13977 AAA99891 XM_005274093 XP_005274150 NM_005040 NP_005031 NM_199418 NP_955450
|
Function |
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
|
Subcellular Location |
Lysosome.
|
Tissue Specificity |
Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
|
Top Pathways |
Protein digestion and absorption
|