Gene Symbol | tll |
---|---|
Entrez Gene | 43656 |
Alt Symbol | CG1378, Dmel\CG1378, NR2E2, TLL, Tll, dm-tll |
Species | Drosophila |
Gene Type | protein-coding |
Description | tailless |
Other Description | CG1378-PA|tailles|tll-PA |
Swissprots | P18102 Q9VA33 Q4V6W1 |
Accessions | AAB71371 AAF57091 P18102 BT022195 AAY51589 M34639 AAA28936 NM_079857 NP_524596 |
Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. {ECO:0000269|PubMed:10357938, ECO:0000269|PubMed:2364433}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
Tissue Specificity | Brain and peripheral nervous system. {ECO:0000269|PubMed:2364433}. |
Top Pathways | MAPK signaling pathway - fly |
Recombinant Drosophila melanogaster Protein tailless(tll) - CSB-YP325960DLU CSB-EP325960DLU CSB-BP325960DLU CSB-MP325960DLU from Cusabio
|
||||||||||
Protein tailless (tll), Recombinant Protein - MBS1090404 from MyBioSource
|
||||||||||
Protein tailless (tll), Recombinant Protein - MBS1155984 from MyBioSource
|
||||||||||