| Gene Symbol | tll |
|---|---|
| Entrez Gene | 43656 |
| Alt Symbol | CG1378, Dmel\CG1378, NR2E2, TLL, Tll, dm-tll |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | tailless |
| Other Description | CG1378-PA|tailles|tll-PA |
| Swissprots | P18102 Q9VA33 Q4V6W1 |
| Accessions | AAB71371 AAF57091 P18102 BT022195 AAY51589 M34639 AAA28936 NM_079857 NP_524596 |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. {ECO:0000269|PubMed:10357938, ECO:0000269|PubMed:2364433}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Tissue Specificity | Brain and peripheral nervous system. {ECO:0000269|PubMed:2364433}. |
| Top Pathways | MAPK signaling pathway - fly |