| Gene Symbol |
Amacr
|
| Entrez Gene |
25284
|
| Alt Symbol |
Da1-8, Marc1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
alpha-methylacyl-CoA racemase
|
| Other Description |
2-arylpropionyl-CoA epimerase|2-methylacyl-CoA racemase
|
| Swissprots |
P70473 O09176
|
| Accessions |
EDL82982 P70473 AY325250 AAP92651 BC078885 AAH78885 BC091163 AAH91163 BC127505 AAI27506 FM061736 U89905 AAB72145 Y08172 CAA69358 NM_012816 NP_036948
|
| Function |
Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Has a role in drug metabolism as well as probably in lipid metabolism. The 2- arylpropionic acid (2-APA's) derivatives, including ibuprofen, are the most widely used anti-inflammatory analgesic cyclooxygenase inhibitors. The (-)-R-enantiomer, which is inactive in terms of cyclooxygenase inhibition, is epimerized in vivo via this enzyme to the cyclooxygenase-inhibiting (+)-S-enantiomer.
|
| Subcellular Location |
Peroxisome. Mitochondrion.
|
| Top Pathways |
Primary bile acid biosynthesis, Peroxisome
|