| Gene Symbol | FCGR2A |
|---|---|
| Entrez Gene | 2212 |
| Alt Symbol | CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
| Other Description | Immunoglobulin G Fc receptor II|fc-gamma RII-a|fc-gamma-RIIa|fcRII-a|igG Fc receptor II-a|low affinity immunoglobulin gamma Fc region receptor II-a |
| Swissprots | Q8WW64 P12318 Q8WUN1 |
| Accessions | AAL99539 ABK41920 CAA01563 CAA48217 P12318 AF416711 AAL78867 AI250177 AK225438 AK225601 AK226059 AK298657 BAH12840 AK298734 BAH12860 AK315225 BAG37654 BC019931 AAH19931 BC020823 AAH20823 DQ892037 ABM82963 DQ895228 ABM86154 J03619 AAA35932 M28697 AAA36050 M31932 AAA35827 X62572 Y00644 CAA68672 XM_011509287 XP_011507589 XM_011509288 XP_011507590 XM_011509289 XP_011507591 XM_011509290 XP_011507592 XM_011509291 XP_011507593 NM_001136219 NP_001129691 NM_021642 NP_067674 |
| Function | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}. |
| Tissue Specificity | Found on monocytes, neutrophils and eosinophil platelets. |
| Top Pathways | Systemic lupus erythematosus, Fc gamma R-mediated phagocytosis, Leishmaniasis, Phagosome, Staphylococcus aureus infection |