Gene Symbol | RAD18 |
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Entrez Gene | 56852 |
Alt Symbol | RNF73 |
Species | Human |
Gene Type | protein-coding |
Description | RAD18 E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase RAD18|RAD18 homolog|RAD18, S. cerevisiae, homolog|RING finger protein 73|hHR18|hRAD18|postreplication repair protein RAD18|postreplication repair protein hRAD18p |
Swissprots | Q9NRT6 Q58F55 Q9NS91 |
Accessions | AAX44049 EAW63948 EAW63949 Q9NS91 AB035274 BAA99284 AF169796 AAF80856 AK023075 BAB14392 AK123966 AK222771 BAD96491 AY004333 AAF86618 BC001302 AAH01302 DQ891197 ABM82123 DQ894380 ABM85306 DW433240 NM_020165 NP_064550 |
Function | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Rad18 CRISPR/Cas9 KO Plasmid (h) - sc-406099 from Santa Cruz Biotechnology
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Rad18 HDR Plasmid (h) - sc-406099-HDR from Santa Cruz Biotechnology
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Rad18 Double Nickase Plasmid (h) - sc-406099-NIC from Santa Cruz Biotechnology
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Rad18 Double Nickase Plasmid (h2) - sc-406099-NIC-2 from Santa Cruz Biotechnology
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Rad18 CRISPR Activation Plasmid (h) - sc-406099-ACT from Santa Cruz Biotechnology
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Rad18 CRISPR Activation Plasmid (h2) - sc-406099-ACT-2 from Santa Cruz Biotechnology
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Rad18 Lentiviral Activation Particles (h) - sc-406099-LAC from Santa Cruz Biotechnology
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Rad18 Lentiviral Activation Particles (h2) - sc-406099-LAC-2 from Santa Cruz Biotechnology
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Rad18 siRNA (h) - sc-72142 from Santa Cruz Biotechnology
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Rad18 shRNA Plasmid (h) - sc-72142-SH from Santa Cruz Biotechnology
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Rad18 shRNA (h) Lentiviral Particles - sc-72142-V from Santa Cruz Biotechnology
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RAD18 RNAi - H00056852-R01V from Novus Biologicals
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RAD18 RNAi - H00056852-R01 from Novus Biologicals
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MISSION® esiRNA - EHU013431 from Sigma-Aldrich
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MISSION® siRNA - SIHK1918 from Sigma-Aldrich
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MISSION® siRNA - SIHK1919 from Sigma-Aldrich
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MISSION® siRNA - SIHK1920 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17892 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17892 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09483 from Sigma-Aldrich
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RAD18 siRNA (Human) - CRJ1189 from Cohesion Biosciences
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RAD18 - MBS8240957 from MyBioSource
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shRNA set against Human RAD18 (NM_020165.3) - SHH388904 from Creative biogene
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Rad18 CRISPR/Cas9 KO Plasmid (h2) - sc-406099-KO-2 from Santa Cruz Biotechnology
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Rad18 HDR Plasmid (h2) - sc-406099-HDR-2 from Santa Cruz Biotechnology
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