SHANK2

Gene Symbol	SHANK2
Entrez Gene	22941
Alt Symbol	AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Species	Human
Gene Type	protein-coding
Description	SH3 and multiple ankyrin repeat domains 2
Other Description	GKAP/SAPAP interacting protein|SH3 and multiple ankyrin repeat domains protein 2|cortactin SH3 domain-binding protein|cortactin-binding protein 1|proline-rich synapse associated protein 1|proline-rich synapse-associated protein 1
Swissprots	Q9UPX8 Q3Y8G9 Q52LK2 Q9UKP1 C0SPG9 C0SPG8
Accessions	AFO66269 AFO66270 EAW74771 EAW74772 EAW74773 EAW74774 EAW74775 EAW74776 EAW74777 EAW74778 EAW74779 Q9UPX8 AA464273 AB028945 BAA82974 AB208025 BAH37016 AB208026 BAH37017 AB208027 BAH37018 AF131790 AF141901 AAF02496 AK095088 AK096045 AK128563 BC041371 BC093885 AAH93885 BC112097 AAI12098 BC113876 BC114484 AAI14485 BC143389 AAI43390 BC168372 AAI68372 BX648718 CV313099 DQ152234 AAZ77790 XM_005277930 XP_005277987 XM_005277932 XP_005277989 XM_006718478 XP_006718541 XM_011544854 XP_011543156 XM_011544855 XP_011543157 XM_011544856 XP_011543158 XM_011544857 XP_011543159 XM_011544858 XP_011543160 XM_011544859 XP_011543161 NM_012309 NP_036441 NM_133266 NP_573573 NR_110766
Function	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular Location	Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 3 is present in epithelial colonic cells (at protein level). {ECO:0000269|PubMed:16293618, ECO:0000269|PubMed:17244609}.
Top Pathways	Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SHANK2 Antibody - 12218 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Shank 1/2/3 (G-12) - sc-393963 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Shank 2 (A-11) - sc-271834 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Shank 2 (H-150) - sc-30192 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Shank 2 (B-4) - sc-365121 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Shank 2 (K-20) - sc-23546 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Shank 2 (P-17) - sc-23545 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SHANK2 antibody - ab101915 from Abcam Host Rabbit Clonality Polyclonal

Anti-SHANK2 antibody - ab189398 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SHANK2 antibody - ab171189 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SHANK2 antibody - ab138126 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SHANK2 antibody [S23B-49] - ab94575 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23B-49

Anti-SHANK2 / SHANK Antibody (clone S23b-6) - LS-C153132 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-6

Anti-SHANK2 / SHANK Antibody (aa84-309) - LS-C124523 from LifeSpan Bioscience Prices $560.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SHANK2 / SHANK Antibody (clone S23b-49) - LS-C153134 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa849-1029) - LS-C182949 from LifeSpan Bioscience Prices $650.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 390) - LS-C230838 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 488) - LS-C230839 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 565) - LS-C230840 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 594) - LS-C230841 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 633) - LS-C230842 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 655) - LS-C230843 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 700) - LS-C230844 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S23b-49

Anti-SHANK2 / SHANK Antibody (aa322-371) - LS-C200666 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SHANK2 / SHANK Antibody (aa1057-1106) - LS-C151610 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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