| Gene Symbol |
IRS1
|
| Entrez Gene |
3667
|
| Alt Symbol |
HIRS-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin receptor substrate 1
|
| Other Description |
IRS-1
|
| Swissprots |
P35568
|
| Accessions |
AAB21608 AGG19175 AGG19176 AGG19177 AHG12642 AHG12643 AHG12644 CAD79961 CBL64020 EAW70838 EAW70839 P35568 AW469017 BC053895 AAH53895 EU831611 ACE87211 EU831698 ACE86532 S62539 AAB27175 NM_005544 NP_005535
|
| Function |
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.
|
| Top Pathways |
AMPK signaling pathway, cGMP-PKG signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer, PI3K-Akt signaling pathway
|