Gene Symbol | Hlcs |
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Entrez Gene | 110948 |
Alt Symbol | 410I21.SP6, D16Jhu34 |
Species | Mouse |
Gene Type | protein-coding |
Description | holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) |
Other Description | biotin apo-protein ligase|biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase|biotin--protein ligase |
Swissprots | Q920N2 |
Accessions | EDL03749 EDL03750 Q920N2 AB066227 BAB68213 AK052424 AK158212 BAE34407 AK164351 AK168925 BAE40738 BC037760 BC050090 AAH50090 XM_006522850 XP_006522913 XM_006522851 XP_006522914 XM_006522852 XP_006522915 XM_006522853 XP_006522916 XM_006522854 XP_006522917 XM_006522855 XP_006522918 XM_006522856 XP_006522919 XM_006523155 XP_006523218 XM_011251409 XP_011249711 NM_139145 NP_631884 |
Function | Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. |
Top Pathways | Biotin metabolism |
HLCS CRISPR/Cas9 KO Plasmid (m) - sc-431072 from Santa Cruz Biotechnology
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HLCS HDR Plasmid (m) - sc-431072-HDR from Santa Cruz Biotechnology
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HLCS Double Nickase Plasmid (m) - sc-431072-NIC from Santa Cruz Biotechnology
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HLCS Double Nickase Plasmid (m2) - sc-431072-NIC-2 from Santa Cruz Biotechnology
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HLCS CRISPR Activation Plasmid (m) - sc-431072-ACT from Santa Cruz Biotechnology
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HLCS CRISPR Activation Plasmid (m2) - sc-431072-ACT-2 from Santa Cruz Biotechnology
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HLCS Lentiviral Activation Particles (m) - sc-431072-LAC from Santa Cruz Biotechnology
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HLCS Lentiviral Activation Particles (m2) - sc-431072-LAC-2 from Santa Cruz Biotechnology
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HCS siRNA (m) - sc-72199 from Santa Cruz Biotechnology
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HCS shRNA Plasmid (m) - sc-72199-SH from Santa Cruz Biotechnology
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HCS shRNA (m) Lentiviral Particles - sc-72199-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU042531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33324 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33324 from Sigma-Aldrich
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HLCS siRNA (Mouse) - CRN1146 from Cohesion Biosciences
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HLCS - MBS8236721 from MyBioSource
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shRNA set against Mouse HLCS (NM_139145.4) - SHH313129 from Creative biogene
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shRNA set against Mouse Hlcs(NM_139145.4) - SHH124427 from Creative biogene
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HLCS shRNA Plasmid (Mouse) - CHN1146 from Cohesion Biosciences
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HLCS miRNA 3'UTR clone - MiUTR1M-05687 from Creative biogene
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