Gene Symbol | Mpo |
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Entrez Gene | 17523 |
Alt Symbol | mKIAA4033 |
Species | Mouse |
Gene Type | protein-coding |
Description | myeloperoxidase |
Other Description | - |
Swissprots | Q5NCP1 P11247 |
Accessions | AAR87486 CAA33439 EDL15833 P11247 AK160229 AK220229 BAD90154 AY500847 AAR99349 BC053912 AAH53912 BY352425 CA547566 CN661559 X15313 CAA33373 XM_006532404 XP_006532467 XM_006532405 XP_006532468 XM_006536437 XP_006536500 XM_006536439 XP_006536502 NM_010824 NP_034954 |
Function | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (By similarity). {ECO:0000250}. |
Subcellular Location | Lysosome. |
Top Pathways | Phagosome, Transcriptional misregulation in cancer |
MPO CRISPR/Cas9 KO Plasmid (m) - sc-421702 from Santa Cruz Biotechnology
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MPO HDR Plasmid (m) - sc-421702-HDR from Santa Cruz Biotechnology
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MPO Double Nickase Plasmid (m) - sc-421702-NIC from Santa Cruz Biotechnology
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MPO Double Nickase Plasmid (m2) - sc-421702-NIC-2 from Santa Cruz Biotechnology
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MPO CRISPR Activation Plasmid (m) - sc-421702-ACT from Santa Cruz Biotechnology
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MPO CRISPR Activation Plasmid (m2) - sc-421702-ACT-2 from Santa Cruz Biotechnology
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MPO Lentiviral Activation Particles (m) - sc-421702-LAC from Santa Cruz Biotechnology
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MPO Lentiviral Activation Particles (m2) - sc-421702-LAC-2 from Santa Cruz Biotechnology
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MPO siRNA (m) - sc-43942 from Santa Cruz Biotechnology
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MPO shRNA Plasmid (m) - sc-43942-SH from Santa Cruz Biotechnology
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MPO shRNA (m) Lentiviral Particles - sc-43942-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN35728 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35728 from Sigma-Aldrich
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MPO siRNA (Mouse) - CRM2585 from Cohesion Biosciences
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shRNA set against Mouse Mpo (NM_010824.2) - SHH343916 from Creative biogene
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MPO shRNA Plasmid (Mouse) - CHM2585 from Cohesion Biosciences
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