| Gene Symbol |
CYBB
|
| Entrez Gene |
281112
|
| Alt Symbol |
NOX2
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
cytochrome b-245, beta polypeptide
|
| Other Description |
CGD91-phox|NADPH oxidase 2|cytochrome b(558) subunit beta|cytochrome b-245 heavy chain|cytochrome b558 subunit beta|gp91-1|gp91-phox|heme-binding membrane glycoprotein gp91phox|neutrophil cytochrome b 91 kDa polypeptide|p22 phagocyte B-cytochrome
|
| Swissprots |
A4IF96 O46522
|
| Accessions |
DAA12704 O46522 AF036097 AAC27247 BC134469 AAI34470 NM_174035 NP_776460
|
| Function |
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation
|