CIDEC
| Gene Symbol | CIDEC |
|---|---|
| Entrez Gene | 63924 |
| Alt Symbol | CIDE-3, CIDE3, FPLD5, FSP27 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell death-inducing DFFA-like effector c |
| Other Description | cell death activator CIDE-3|fat specific protein 27 |
| Swissprots | Q67DW9 C9JMN7 Q9GZY9 Q96AQ7 |
| Accessions | CAC09160 EAW64011 EAW64012 EAW64013 EAW64014 Q96AQ7 AF303893 AAN32612 AK024524 BAB14920 AK024530 BAB14922 AL598630 AL598731 AY364638 AAR23106 AY364640 AAQ65242 BC016851 AAH16851 CD518729 CD519587 HQ447102 ADQ31589 XM_005265374 XP_005265431 XM_005265375 XP_005265432 XM_005265376 XP_005265433 NM_001199551 NP_001186480 NM_001199552 NP_001186481 NM_001199623 NP_001186552 NM_022094 NP_071377 |
| Function | Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulatio |
| Subcellular Location | Nucleus {ECO:0000250}. Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. |
| Tissue Specificity | Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver. {ECO:0000269|PubMed:12429024, ECO:0000269|PubMed:18334488}. |
CIDE-C CRISPR/Cas9 KO Plasmid (h) - sc-416800 from Santa Cruz Biotechnology
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CIDE-C HDR Plasmid (h) - sc-416800-HDR from Santa Cruz Biotechnology
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CIDE-C Double Nickase Plasmid (h) - sc-416800-NIC from Santa Cruz Biotechnology
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CIDE-C Double Nickase Plasmid (h2) - sc-416800-NIC-2 from Santa Cruz Biotechnology
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CIDE-C CRISPR Activation Plasmid (h) - sc-416800-ACT from Santa Cruz Biotechnology
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CIDE-C CRISPR Activation Plasmid (h2) - sc-416800-ACT-2 from Santa Cruz Biotechnology
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CIDE-C Lentiviral Activation Particles (h) - sc-416800-LAC from Santa Cruz Biotechnology
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CIDE-C Lentiviral Activation Particles (h2) - sc-416800-LAC-2 from Santa Cruz Biotechnology
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CIDE-C siRNA (h) - sc-78016 from Santa Cruz Biotechnology
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CIDE-C shRNA Plasmid (h) - sc-78016-SH from Santa Cruz Biotechnology
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CIDE-C shRNA (h) Lentiviral Particles - sc-78016-V from Santa Cruz Biotechnology
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CIDEC RNAi - H00063924-R01 from Novus Biologicals
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MISSION® esiRNA - EHU111051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6132 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6132 from Sigma-Aldrich
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CIDEC siRNA (Human) - CRJ1864 from Cohesion Biosciences
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CIDEC - MBS8221983 from MyBioSource
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shRNA set against Human CIDEC (NM_022094.3) - SHH264073 from Creative biogene
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Human CIDEC siRNA - orb272365 from Biorbyt
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CIDEC shRNA Plasmid (Human) - CHJ1864 from Cohesion Biosciences
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CIDEC miRNA 3'UTR clone - MiUTR3H-12304 from Creative biogene
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