Gene Symbol | MBIP |
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Entrez Gene | 51562 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | MAP3K12 binding inhibitory protein 1 |
Other Description | MAP3K12-binding inhibitory protein 1|MAPK upstream kinase-binding inhibitory protein|MUK-binding inhibitory protein |
Swissprots | Q9BS93 Q86TZ2 Q9NZE1 Q96AS5 Q9NS73 |
Accessions | EAW65862 EAW65863 EAW65864 EAW65865 Q9NS73 AA761503 AB038523 BAA94083 AF208857 AAF64271 AK293473 BAG56966 AK315290 BAG37697 BC005197 AAH05197 BC016821 AAH16821 BX248287 CAD62615 HQ447190 ADQ31677 XM_005267754 XP_005267811 XM_005267755 XP_005267812 XM_005267756 XP_005267813 XM_011536833 XP_011535135 NM_001144891 NP_001138363 NM_001308110 NP_001295039 NM_016586 NP_057670 |
Function | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12. |
Tissue Specificity | Ubiquitous. High expression seen in the heart and lung. |
MBIP CRISPR/Cas9 KO Plasmid (h) - sc-412220 from Santa Cruz Biotechnology
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MBIP HDR Plasmid (h) - sc-412220-HDR from Santa Cruz Biotechnology
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MBIP Double Nickase Plasmid (h) - sc-412220-NIC from Santa Cruz Biotechnology
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MBIP Double Nickase Plasmid (h2) - sc-412220-NIC-2 from Santa Cruz Biotechnology
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MBIP CRISPR Activation Plasmid (h) - sc-412220-ACT from Santa Cruz Biotechnology
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MBIP CRISPR Activation Plasmid (h2) - sc-412220-ACT-2 from Santa Cruz Biotechnology
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MBIP Lentiviral Activation Particles (h) - sc-412220-LAC from Santa Cruz Biotechnology
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MBIP Lentiviral Activation Particles (h2) - sc-412220-LAC-2 from Santa Cruz Biotechnology
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MBIP siRNA (h) - sc-92120 from Santa Cruz Biotechnology
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MBIP shRNA Plasmid (h) - sc-92120-SH from Santa Cruz Biotechnology
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MBIP shRNA (h) Lentiviral Particles - sc-92120-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU067791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13081 from Sigma-Aldrich
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MBIP siRNA (Human) - CRH9834 from Cohesion Biosciences
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MBIP shRNA Plasmid (Human) - CHH9834 from Cohesion Biosciences
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MBIP miRNA 3'UTR clone - MiUTR3H-10603 from Creative biogene
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MBIP miRNA 3'UTR clone - MiUTR3H-10604 from Creative biogene
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