IL17C

Gene Symbol IL17C
Entrez Gene 27189
Alt Symbol CX2, IL-17C
Species Human
Gene Type protein-coding
Description interleukin 17C
Other Description cytokine CX2|interleukin-17C
Swissprots Q3MIG8 Q9P0M4 Q9HC75
Accessions CAH18037 CAL40892 CAO02250 CAS97406 CAT03419 EAW66798 Q9P0M4 AF152099 AAF28105 AY358471 AAQ88835 BC069152 AAH69152 BC069410 BC101835 AAI01836 BC112196 AAI12197 NM_013278 NP_037410
Function Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269|PubMed:21993848}.
Subcellular Location Secreted.

IL-17C CRISPR/Cas9 KO Plasmid (h) - sc-409895 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C HDR Plasmid (h) - sc-409895-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C Double Nickase Plasmid (h) - sc-409895-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C Double Nickase Plasmid (h2) - sc-409895-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C CRISPR Activation Plasmid (h) - sc-409895-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C CRISPR Activation Plasmid (h2) - sc-409895-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C Lentiviral Activation Particles (h) - sc-409895-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C Lentiviral Activation Particles (h2) - sc-409895-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-17C siRNA (h) - sc-39653 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-17C shRNA Plasmid (h) - sc-39653-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-17C shRNA (h) Lentiviral Particles - sc-39653-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10577 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03389 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03389

IL17C siRNA (Human) - CRH9016 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL17C - MBS8240045 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL17C (NM_013278.3) - SHH318317 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IL17C(NM_013278.3) - SHL171540 from Creative biogene

Category siRNA
Species Reactivities Human

IL17C shRNA Plasmid (Human) - CHH9016 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL17C miRNA 3'UTR clone - MiUTR1H-04879 from Creative biogene

Species Reactivities Human
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