ZC3HAV1
| Gene Symbol | ZC3HAV1 |
|---|---|
| Entrez Gene | 56829 |
| Alt Symbol | ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger CCCH-type, antiviral 1 |
| Other Description | ADP-ribosyltransferase diphtheria toxin-like 13|zinc finger CCCH domain-containing protein 2|zinc finger CCCH-type antiviral protein 1 |
| Swissprots | A4D1S4 Q9P0Y7 A4D1R2 Q8IW57 Q9H8R9 Q8TAJ3 Q7Z2W4 Q96N79 |
| Accessions | EAL24040 EAL24041 EAW83902 EAW83903 EAW83904 EAW83905 Q7Z2W4 AF138863 AAF61195 AK023350 BAB14537 AK055851 BAB71028 AK098308 AK292811 BAF85500 BC002935 AAH02935 BC025308 AAH25308 BC027462 AAH27462 BC033105 AAH33105 BC038809 BC040956 AAH40956 BX571742 CAE11868 BX647138 BX647974 XM_005250501 XP_005250558 XM_011516412 XP_011514714 NM_020119 NP_064504 NM_024625 NP_078901 |
| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a mor |
| Subcellular Location | Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}. |
ZAP CRISPR/Cas9 KO Plasmid (h) - sc-407495 from Santa Cruz Biotechnology
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ZAP HDR Plasmid (h) - sc-407495-HDR from Santa Cruz Biotechnology
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ZAP Double Nickase Plasmid (h) - sc-407495-NIC from Santa Cruz Biotechnology
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ZAP Double Nickase Plasmid (h2) - sc-407495-NIC-2 from Santa Cruz Biotechnology
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ZAP CRISPR Activation Plasmid (h) - sc-407495-ACT from Santa Cruz Biotechnology
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ZAP CRISPR Activation Plasmid (h2) - sc-407495-ACT-2 from Santa Cruz Biotechnology
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ZAP Lentiviral Activation Particles (h) - sc-407495-LAC from Santa Cruz Biotechnology
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ZAP Lentiviral Activation Particles (h2) - sc-407495-LAC-2 from Santa Cruz Biotechnology
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ZAP siRNA (h) - sc-89362 from Santa Cruz Biotechnology
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ZAP shRNA Plasmid (h) - sc-89362-SH from Santa Cruz Biotechnology
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ZAP shRNA (h) Lentiviral Particles - sc-89362-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU081401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1326 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1326 from Sigma-Aldrich
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ZC3HAV1 siRNA (Human) - CRJ1181 from Cohesion Biosciences
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ZCCHV RNAi - H00056829-R02 from Novus Biologicals
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ZCCHV RNAi - H00056829-R01 from Novus Biologicals
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ZC3HAV1 - MBS8219998 from MyBioSource
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ZAP CRISPR/Cas9 KO Plasmid (h2) - sc-407495-KO-2 from Santa Cruz Biotechnology
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ZAP HDR Plasmid (h2) - sc-407495-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ZC3HAV1 (NM_020119.3) - SHH449528 from Creative biogene
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shRNA set against Human ZC3HAV1(NM_024625.3) - SHL143364 from Creative biogene
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shRNA set against Human ZC3HAV1(NM_020119.3) - SHL143424 from Creative biogene
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Human ZC3HAV1 siRNA - orb271682 from Biorbyt
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ZC3HAV1 shRNA Plasmid (Human) - CHJ1181 from Cohesion Biosciences
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