| Gene Symbol | HLA-DQA1 |
|---|---|
| Entrez Gene | 3117 |
| Alt Symbol | CD, CELIAC1, DQ-A1, GSE, HLA-DQA |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DQ alpha 1 |
| Other Description | DC-1 alpha chain|DC-alpha|HLA class II histocompatibility antigen, DQ alpha 1 chain|HLA class II histocompatibility antigen, DQ(W3) alpha chain|HLA-DCA|MHC HLA-DQ alpha|MHC class II DQA1|MHC class II HLA-D alpha glycoprotein|MHC class II HLA-DQ-alpha-1|MHC class II antigen|MHC class II surface glycoprotein|leucocyte antigen DQA1|leukocyte antigen alpha chain |
| Swissprots | Q6ICU6 Q860W2 Q30071 Q2Q6Y8 Q30068 P01907 Q29876 Q6PR46 Q30101 Q2WCM3 Q30086 P04226 Q30067 Q30070 Q5Y7D5 Q9UM31 P04225 P05536 Q2Q6Y6 P79553 Q6QDB1 Q9BD37 Q29994 Q2Q6Y7 Q30073 O19706 Q5Y7F5 Q9TPM3 Q06751 P01909 O19630 Q30064 P01908 Q30072 Q860W4 |
| Accessions | AAA59756 AAA59757 AAA59759 AAA74633 AAB32621 AAB41891 AAB58310 AAB60341 AAB91990 AAD49219 AAD56720 AAK11577 AAM69677 AAM74914 AAM74915 AAM74916 AAM74917 AAM74918 AAM74919 AAM74920 AAO23559 AAO45622 AAO46067 AAO46068 AAO46069 AAO46070 AAO46071 AAO46073 AAO46074 AAO46076 AAO47362 AAQ89959 AAQ89960 AAQ89961 AAQ89962 AAQ89963 AAQ89964 AAQ89965 AAQ89966 AAQ89967 AAQ89968 AAQ89969 AAQ89974 AAQ89976 AAQ89977 AAQ89978 AAQ89982 AAQ89983 AAQ89984 AAQ89985 AAQ89986 AAQ89987 AAQ89988 AAQ89989 AAQ89990 AAQ89991 AAQ91390 AAQ91391 AAQ91392 AAQ91393 AAQ91394 AAQ91395 AAQ91396 AAQ91397 AAQ91398 AAQ91399 AAQ91400 AAQ91401 AAQ91402 AAQ91411 AAQ91412 AAQ91413 AAQ91414 AAQ91415 AAQ91416 AAQ91417 AAQ91418 AAQ91419 AAQ91420 AAQ91421 AAQ91422 AAQ91423 AAQ91424 AAQ91425 AAQ91426 AAQ91427 AAQ91428 AAQ91429 AAQ91430 AAQ91431 AAQ91432 AAS49496 AAT09985 AAU87975 AAU87978 AAU87981 AAU87984 AAU87992 AAU88004 AAU88007 AAU88013 AAU88016 AAU88022 AAU88025 AAU88028 AAU88031 AAU88034 ABA86855 ABA86856 ABA86857 ABA86858 ACY06698 AEP60144 AEP60145 AHW47921 AHW47938 AHW47955 AHW47972 BAA22189 CAB06491 CAC88114 CAJ14960 CAJ14961 CAL08011 CAL08012 CAL08013 CBL53179 CCJ47270 CCJ47271 CCJ47272 CCJ51907 CCJ51908 CCK73388 CCK73389 CCK73390 CCQ26874 CCV19549 CDG66212 CDL92963 CDO39025 CEO86978 EAW50504 EAW50505 P01909 AB209628 BAD92865 AF012768 AAB70189 AF522250 AAP80750 AF533895 AAM94809 AF533896 AAM94810 AF533897 AAM94811 AF533898 AAM94812 AF533899 AAM94813 AF533900 AAM94814 AF533901 AAM94815 AF533902 AAM94816 AF533903 AAM94817 AF533904 AAM94818 AF533905 AAM94819 AF533906 AAM94820 AF533907 AAM94821 AF533908 AAM94822 AF533909 AAM94823 AF533910 AAM94824 AF533911 AAM94825 AF533912 AAM94826 AF533913 AAM94827 AF533914 AAM94828 AF533915 AAM94829 AF533916 AAM94830 AF533917 AAM94831 AF533918 AAM94832 AF533919 AAM94833 AF533920 AAM94834 AF533921 AAM94835 AF533922 AAM94836 AF533923 AAM94837 AF533924 AAM94838 AF533925 AAM94839 AF533926 AAM94840 AF533927 AAM94841 AF533928 AAM94842 AF533929 AAM94843 AF533930 AAM94844 AF533931 AAM94845 AF533932 AAM94846 AF533933 AAM94847 AF533934 AAM94848 AF533935 AAM94849 AF533936 AAM94850 AF533937 AAM94851 AF533938 AAM94852 AF533939 AAM94853 AF533940 AAM94854 AK130598 AK130811 AK130838 AK297065 BAG59586 AK313975 BAG36689 BC008585 AAH08585 BC051832 BC073977 AAH73977 BC125044 AAI25045 BC125045 AAI25046 BC157865 AAI57866 BC171877 AAI71877 BU617246 CR450297 CAG29293 DQ284436 ABC66202 DQ284437 ABC66203 DQ284438 ABC66204 DQ284439 ABC66205 DQ284440 ABC66206 DQ891535 ABM82461 DQ894724 ABM85650 J00199 JF895477 AEP60146 L34082 AAC41950 L34083 AAC41951 L34084 AAC41952 L34085 AAC41953 L34086 AAC41954 L34087 AAC41955 L34088 AAC41956 L34090 AAC41958 L34091 AAC41959 L34092 AAC41960 L34093 AAC41961 L34094 AAC41962 L42625 AAA85334 L46875 L46877 L46878 L46879 L46880 L46881 M11124 AAA59754 M16995 AAA59760 M17846 AAA59707 M17847 AAA59708 M18935 AAA59784 M20431 AAA59758 M20506 AAA59774 M26041 AAA36267 M33906 AAA52671 M34996 AAA35771 M59802 AAA64233 U77589 AAB51233 X00033 CAA24917 X00370 X00452 CAA25141 XM_003846468 XP_003846516 XM_005274953 XP_005275010 XM_005275108 XP_005275165 XM_005275542 XP_005275599 XM_006715079 XP_006715142 XM_006725484 XP_006725547 XM_006725999 XP_006726062 XM_011547645 XP_011545947 XM_011547876 XP_011546178 NM_002122 NP_002113 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection |