| Gene Symbol |
Trp53bp2
|
| Entrez Gene |
209456
|
| Alt Symbol |
53BP2, AI746547, ASPP2, PPP1R13A, Tp53bp2, X98550
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transformation related protein 53 binding protein 2
|
| Other Description |
apoptosis-stimulating of p53 protein 2|p53-binding protein 2|p53BP2|tumor protein p53 binding protein, 2|tumor suppressor p53-binding protein 2
|
| Swissprots |
Q8K2L5 Q3UYM7 Q8CG79
|
| Accessions |
EDL13107 Q8CG79 AK133930 BAE21932 AK134556 BAE22185 AK189404 AK195318 AW990556 BC025187 BC030894 AAH30894 BC042874 BQ180182 BY020445 CN529251 NM_173378 NP_775554
|
| Function |
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. {ECO:0000250}.
|
| Top Pathways |
Hippo signaling pathway
|