TCF7

Gene Symbol	TCF7
Entrez Gene	6932
Alt Symbol	TCF-1
Species	Human
Gene Type	protein-coding
Description	transcription factor 7 (T-cell specific, HMG-box)
Other Description	T-cell-specific transcription factor 1|transcription factor 7
Swissprots	Q9UKI4 P36402 Q86WR9 B3KSH3
Accessions	AAF00616 CAB56795 CAY55999 CAY56000 CAY56001 CAY56002 CBX53858 CBX53859 CBX53860 CBX53861 CBX53862 EAW62277 EAW62278 EAW62279 EAW62280 P36402 AK057580 BAG51937 AK093530 BAG52735 AK093683 BAG52748 AK131428 AK310591 AL832816 AL834166 BC048769 AAH48769 BC072023 AAH72023 DA627229 DB127975 DB137814 DB145426 EU446661 ABZ92190 X59869 CAA42526 X59870 CAA42527 X59871 CAA42528 Z47361 CAA87439 Z47362 CAA87440 Z47363 CAA87441 Z47364 CAA87442 XM_006714678 XP_006714741 XM_006714679 XP_006714742 XM_006714680 XP_006714743 XM_006714682 XP_006714745 XM_006714684 XP_006714747 XM_006714685 XP_006714748 XM_006714686 XP_006714749 XM_006714687 XP_006714750 XM_011543604 XP_011541906 XM_011543605 XP_011541907 XM_011543606 XP_011541908 XM_011543607 XP_011541909 XM_011543608 XP_011541910 XM_011543609 XP_011541911 XM_011543610 XP_011541912 XM_011543611 XP_011541913 XM_011543612 XP_011541914 XM_011543613 XP_011541915 XR_948292 XR_948293 XR_948294 NM_001134851 NP_001128323 NM_003202 NP_003193 NM_201632 NP_963963 NM_201634 NP_963965 NM_213648 NP_998813 NR_033449 NM_001134852
Function	Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Subcellular Location	Nucleus.
Tissue Specificity	Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. {ECO:0000269|PubMed:10489374}.
Top Pathways	Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TCF1/TCF7 (C63D9) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 6709 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone C63D9

TCF1/TCF7 (C63D9) Rabbit mAb (Pacific Blue™ Conjugate) - 9066 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone C63D9

TCF1/TCF7 (C63D9) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 6444 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone C63D9

TCF1/TCF7 (C63D9) Rabbit mAb (PE Conjugate) - 14456 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone C63D9

TCF1/TCF7 (C63D9) Rabbit mAb - 2203 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C63D9

TCF1/TCF7 (C46C7) Rabbit mAb - 2206 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C46C7

TCF-1 (C-5) - sc-271453 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TCF-1 (H-118) - sc-13025 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TCF-1 (H-18) - sc-8589 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TCF-1 (A-79) - sc-101170 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

TCF-1A (C-21) - sc-8590 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TCF7 antibody - ab30961 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 antibody - ab58271 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TCF7 antibody - ab64947 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TCF7 antibody - ab183862 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 antibody - ab90136 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 antibody [EPR2035] - ab134127 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2035

Anti-TCF7 antibody - N-terminal - ab71251 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (N-Terminus, Biotin) - LS-C283674 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (aa10-59) - LS-C118876 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (C-Terminus) - LS-C109590 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (N-Terminus, Azide-free, HRP) - LS-C283675 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (aa3-36) - LS-C97577 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (N-Terminus, FITC) - LS-C283676 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TCF7 Antibody (N-Terminus, PE) - LS-C283677 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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