Gene Symbol | HTR3C |
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Entrez Gene | 170572 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic |
Other Description | 5-HT3-C|5-HT3C|5-hydroxytryptamine (serotonin) receptor 3, family member C|5-hydroxytryptamine receptor 3 subunit C|5-hydroxytryptamine receptor 3C|serotonin receptor 3C |
Swissprots | Q8WXA8 A2RRR5 |
Accessions | EAW78305 Q8WXA8 AF459285 AAL66182 BC131799 AAI31800 NM_130770 NP_570126 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000269|PubMed:17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
Tissue Specificity | Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. {ECO:0000269|PubMed:12801637}. |
HTR3C CRISPR/Cas9 KO Plasmid (h) - sc-414932 from Santa Cruz Biotechnology
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HTR3C HDR Plasmid (h) - sc-414932-HDR from Santa Cruz Biotechnology
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HTR3C Double Nickase Plasmid (h) - sc-414932-NIC from Santa Cruz Biotechnology
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HTR3C Double Nickase Plasmid (h2) - sc-414932-NIC-2 from Santa Cruz Biotechnology
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HTR3C CRISPR Activation Plasmid (h) - sc-414932-ACT from Santa Cruz Biotechnology
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HTR3C CRISPR Activation Plasmid (h2) - sc-414932-ACT-2 from Santa Cruz Biotechnology
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HTR3C Lentiviral Activation Particles (h) - sc-414932-LAC from Santa Cruz Biotechnology
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HTR3C Lentiviral Activation Particles (h2) - sc-414932-LAC-2 from Santa Cruz Biotechnology
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HTR3C siRNA (h) - sc-78193 from Santa Cruz Biotechnology
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HTR3C shRNA Plasmid (h) - sc-78193-SH from Santa Cruz Biotechnology
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HTR3C shRNA (h) Lentiviral Particles - sc-78193-V from Santa Cruz Biotechnology
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5-HT3C RNAi - H00170572-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2527 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2527 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02123 from Sigma-Aldrich
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HTR3C siRNA (Human) - CRJ6113 from Cohesion Biosciences
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HTR3C - MBS8220041 from MyBioSource
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shRNA set against Human HTR3C (NM_130770.2) - SHH315973 from Creative biogene
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Human HTR3C siRNA - orb276614 from Biorbyt
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HTR3C shRNA Plasmid (Human) - CHJ6113 from Cohesion Biosciences
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HTR3C miRNA 3'UTR clone - MiUTR1H-04755 from Creative biogene
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