| Gene Symbol |
DROSHA
|
| Entrez Gene |
29102
|
| Alt Symbol |
ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
drosha, ribonuclease type III
|
| Other Description |
RNase III|drosha, double-stranded RNA-specific endoribonuclease|nuclear RNase III Drosha|p241|protein Drosha|putative protein p241 which interacts with transcription factor Sp1|putative ribonuclease III|ribonuclease 3|ribonuclease III, nuclear|ribonuclease type III, nuclear
|
| Swissprots |
Q9Y4Y0 Q7Z5V2 Q86YH0 Q9Y2V9 E7EMP9 Q9NRR4 Q9NW73
|
| Accessions |
CBM42910 CBV35643 EAX10767 EAX10768 EAX10769 EAX10770 Q9NRR4 AA917625 AB209501 BAD92738 AF116910 AAD29637 AF189011 AAF80558 AJ242976 CAB45133 AK001121 BAA91511 AK026563 AK308093 BC024261 BC041162 AAH41162 BC054003 AAH54003 BX647724 DB065470 XM_005248291 XP_005248348 XM_005248292 XP_005248349 XM_005248293 XP_005248350 XM_005248294 XP_005248351 XM_011514033 XP_011512335 NM_001100412 NP_001093882 NM_013235 NP_037367
|
| Function |
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10948199}.
|
| Top Pathways |
Ribosome biogenesis in eukaryotes, Proteoglycans in cancer
|