| Gene Symbol | ARAP3 |
|---|---|
| Entrez Gene | 64411 |
| Alt Symbol | CENTD3, DRAG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Other Description | ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3|centaurin, delta 3|centaurin-delta-3|cnt-d3|phosphoinositide binding protein |
| Swissprots | D3DQE3 Q8WWN8 B4DIT1 |
| Accessions | EAW61904 EAW61905 EAW61906 EAW61907 Q8WWN8 AJ310567 CAC83946 AK001579 BAG50942 AK024718 BAB14973 AK091385 AK290052 BAF82741 AK295768 BAG58593 BC009968 AAH09968 BC025757 AAH25757 BC027880 AAH27880 BX489939 XM_005268497 XP_005268554 XM_005268498 XP_005268555 XM_005268499 XP_005268556 XM_005268500 XP_005268557 XM_006714792 XP_006714855 XM_011537677 XP_011535979 XR_944326 XR_944327 XR_944328 XR_944329 NM_022481 NP_071926 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}. |
| Top Pathways | Endocytosis, cAMP signaling pathway, Rap1 signaling pathway |
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), Human, ELISA Kit - E01A1622 from ARP American Research Products
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Arf GAP with Rho GAP domain, ANK repeat and PH domain containing protein 3 (ARAP3), ELISA Kit - MBS7208113 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7250701 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7222046 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7227183 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7210851 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7242110 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7247487 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7202186 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7243160 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7222431 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7245504 from MyBioSource
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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), ELISA Kit - MBS7242484 from MyBioSource
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Centaurin Delta 3 (CENTd3), ELISA Kit - MBS9302156 from MyBioSource
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Human ARAP3 ELISA Kit - E003574 from Biobool
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Human CENTd3 ELISA Kit - E007742 from Biobool
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anti-ARAP3 antibody - ARG63376 from Arigo Biolaboratories
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