ELOVL4

Gene Symbol ELOVL4
Entrez Gene 6785
Alt Symbol ADMD, CT118, ISQMR, SCA34, STGD2, STGD3
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 4
Other Description 3-keto acyl-CoA synthase ELOVL4|ELOVL FA elongase 4|cancer/testis antigen 118|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4|elongation of very long chain fatty acids protein 4|very-long-chain 3-oxoacyl-CoA synthase 4
Swissprots Q86YJ1 B2R6B5 Q5TCS2 Q9H139 Q9GZR5
Accessions AAG47669 EAW48701 Q9GZR5 AF277094 AAG47668 AJ420478 AK055277 BAB70895 AK310625 AK312511 BAG35412 AY037298 AAK68639 BC038506 AAH38506 DA122864 DQ426871 DQ891229 ABM82155 HQ447854 ADQ32338 NM_022726 NP_073563
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255}.
Tissue Specificity Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation

ELOVL4 CRISPR/Cas9 KO Plasmid (h) - sc-407562 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 HDR Plasmid (h) - sc-407562-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 Double Nickase Plasmid (h) - sc-407562-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 Double Nickase Plasmid (h2) - sc-407562-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 CRISPR Activation Plasmid (h) - sc-407562-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 CRISPR Activation Plasmid (h2) - sc-407562-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 Lentiviral Activation Particles (h) - sc-407562-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 Lentiviral Activation Particles (h2) - sc-407562-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL4 siRNA (h) - sc-60574 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL4 shRNA Plasmid (h) - sc-60574-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL4 shRNA (h) Lentiviral Particles - sc-60574-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU028431 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7823 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7823 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ELOVL4 siRNA (Human) - CRH4641 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELOVL4 RNAi - H00006785-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ELOVL4 - MBS8202546 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ELOVL4 (NM_022726.3) - SHH285281 from Creative biogene

Category siRNA
Species Reactivities Human

ELOVL4 shRNA Plasmid (Human) - CHH4641 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ELOVL4 miRNA 3'UTR clone - MiUTR3H-07746 from Creative biogene

Species Reactivities Human
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