| Gene Symbol |
Notch3
|
| Entrez Gene |
18131
|
| Alt Symbol |
AW229011, N3, hpbk
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
notch 3
|
| Other Description |
Notch gene homolog 3|neurogenic locus notch homolog protein 3
|
| Swissprots |
Q61982
|
| Accessions |
EDL40331 Q61982 BC172738 AAI72738 X74760 CAA52776 NM_008716 NP_032742
|
| Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Proliferating neuroepithelium.
|
| Top Pathways |
Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation
|