MAPKAPK5

Gene Symbol MAPKAPK5
Entrez Gene 8550
Alt Symbol MAPKAP-K5, MK-5, MK5, PRAK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase-activated protein kinase 5
Other Description MAP kinase-activated protein kinase 5|MAPK-activated protein kinase 5|MAPKAP kinase 5|MAPKAPK-5|p38-regulated/activated protein kinase
Swissprots Q86X46 B3KVA5 Q9UG86 Q9BVX9 O60491 Q8IW41
Accessions AAC39863 EAW97979 EAW97980 EAW97981 Q8IW41 AK122767 BAG53717 AL110301 CAB53747 AW780199 BC000833 AAH00833 BC041049 AAH41049 BC047284 AAH47284 BG502445 XM_005253979 XP_005254036 XM_011538909 XP_011537211 XM_011538910 XP_011537212 XM_011538911 XP_011537213 XM_011538912 XP_011537214 XM_011538913 XP_011537215 XM_011538914 XP_011537216 XM_011538915 XP_011537217 XM_011538916 XP_011537218 XM_011538917 XP_011537219 XM_011538918 XP_011537220 XM_011538919 XP_011537221 XM_011538920 XP_011537222 XM_011538921 XP_011537223 XM_011538922 XP_011537224 XR_944806 XR_944807 NM_003668 NP_003659 NM_139078 NP_620777
Function Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ER
Subcellular Location Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
Tissue Specificity Expressed ubiquitously. {ECO:0000269|PubMed:9628874}.
Top Pathways MAPK signaling pathway

HTScan® MAPKAPK-5 Kinase Assay Kit - 7660 from Cell Signaling Technology

Category Assay Kit
Figure 1. MAPKAPK-5 kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, ATP, variable, 2.5 µg/50 µl PEG20.000, Substrate: Tetra (LRRWSLG), 3 µg/50 µl and recombinant MAPKAPK-5: 200 ng/50 µl.

Mouse/Human Phospho-MAPKAPK5 / PRAK (Thr182) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1735 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human MAPKAPK5 / PRAK ELISA Kit (Cell-Based ELISA) - LS-F2129 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

MAPKAPK5 (Human) IP-WB Antibody Pair - H00008550-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

MAPKAPK5 (Human) Matched Antibody Pair - H00008550-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

MAPKAPK5 Colorimetric Cell-Based ELISA Kit - CB5429 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

MAPKAPK5 (Phospho-Thr182) Colorimetric Cell-Based ELISA Kit - CBP1825 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

mitogen-activated protein kinase-activated protein kinase 5, ELISA Kit - MBS9318402 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/ml.
Range 0.5 ng/ml - 16 ng/ml.

MAPKAPK5 (Phospho-Thr182) ELISA Kit - DEIA-XYA1879 from Creative Diagnostics

Category ELISA Kit

Human MAPKAPK5 ELISA Kit - E089157 from Biobool

Category ELISA Kit

Human MAP kinase-activated protein kinase 5 (MAPKAPK5) ELISA Kit - AE34268HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9349462 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9359827 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9344007 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9343876 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9368775 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9350624 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9346831 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9343840 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9364152 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9365228 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9358974 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9348846 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9347759 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5), ELISA Kit - MBS9351706 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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