PRKX

Gene Symbol PRKX
Entrez Gene 5613
Alt Symbol PKX1
Species Human
Gene Type protein-coding
Description protein kinase, X-linked
Other Description cAMP-dependent protein kinase catalytic subunit PRKX|protein kinase PKX1|protein kinase X|protein kinase X-linked|serine/threonine-protein kinase PRKX
Swissprots P51817
Accessions CBX55118 EAW98726 EAW98727 EAW98728 P51817 BC041073 AAH41073 BE675757 DN996851 DN997580 EU832357 ACE87614 EU832442 ACE86927 X85545 CAA59733 XM_005274560 XP_005274617 XM_005274561 XP_005274618 XM_011545544 XP_011543846 NM_005044 NP_005035
Function Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.
Subcellular Location Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Tissue Specificity Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269|PubMed:15879576, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:7633447, ECO:0000269|PubMed:9860982}.
Top Pathways Adrenergic signaling in cardiomyocytes, Ovarian steroidogenesis, Wnt signaling pathway, Proteoglycans in cancer, Estrogen signaling pathway

PRKY/X (H-120) - sc-67384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRKY/X (H-120): sc-67384. Western blot analysis of PRKY/X expression in human liver tissue extract.

Anti-PRKX antibody - ab154739 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PRKX antibody (ab154739) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-PRKX antibody - ab137941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PRKX antibody (ab137941) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-PRKX antibody - ab67446 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PRKX antibody (ab67446) at 1/500 dilution + human liver tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-PRKX antibody - ab98196 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PRKX antibody (ab98196) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PRKX antibody [EPR4840] - ab109389 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4840
All lanes : Anti-PRKX antibody [EPR4840] (ab109389) at 1/1000 dilutionLane 1 : A549 cell lysatesLane 2 : Jurkat cell lysatesLane 3 : 293T cell lysatesLane 4 : Human fetal kidney lysatesLane 5 : Human fetal brain lysatesLysates/proteins at 10 µg per lane.

Anti-PRKX antibody - C-terminal - ab71619 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRKX antibody - C-terminal (ab71619) at 1/100 dilutionLane 1 : Jurkat cell lysateLane 2 : Mouse brain tissue lysateLysates/proteins at 12.5 µg per lane.

Anti-PRKX Antibody (aa1-30, FITC) - LS-C267141 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa1-30, Azide-free, HRP) - LS-C267143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa249-298) - LS-C200529 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using PRKX antibody.

Anti-PRKX Antibody (aa1-30, PE) - LS-C267142 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, AP) - LS-C281478 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, APC) - LS-C281480 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, FITC) - LS-C281483 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, Biotin) - LS-C281484 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, PE) - LS-C281486 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (C-Terminus, Azide-free, HRP) - LS-C281485 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa1-30, AP) - LS-C284773 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa1-30, APC) - LS-C284774 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (N-Terminus) - LS-C107757 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRKX antibody LS-C107757 Western blot of HepG2 cell lysate.

Anti-PRKX Antibody (Internal, clone EPR4840) - LS-C138615 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4840
Western blot analysis on (A) A549, (B) Jurkat, (C) 293T, (D) fetal kidney, and (E) fetal brain lysates using anti-PRKX antibody.

Anti-PRKX Antibody (aa312-343) - LS-C99731 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PRKX antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PRKX Antibody (aa1-30, Biotin) - LS-C284777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa308-353) - LS-C313891 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKX Antibody (aa1-30) - LS-C330015 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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