Gene Symbol | SGCB |
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Entrez Gene | 6443 |
Alt Symbol | A3b, LGMD2E, SGC |
Species | Human |
Gene Type | protein-coding |
Description | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
Other Description | 43 kDa dystrophin-associated glycoprotein|43DAG|beta-SG|beta-sarcoglycan|beta-sarcoglycan(43kD dystrophin-associated glycoprotein)|limb girdle muscular dystrophy 2E (non-linked families) |
Swissprots | Q16585 B7Z635 O00661 |
Accessions | AAB46956 CAA70920 EAX05429 EAX05430 Q16585 AK094731 AK289892 BAF82581 AK299765 BAH13121 BC020709 AAH20709 BC048972 BT019433 AAV38240 CA449352 CN483961 CR456810 CAG33091 DQ893140 ABM84066 DQ896425 ABM87424 EU176433 ABW03884 U29586 AAB41291 U31116 AAA87034 XM_006714049 XP_006714112 XM_011534403 XP_011532705 XM_011534404 XP_011532706 NM_000232 NP_000223 |
Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Subcellular Location | Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
Tissue Specificity | Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Human beta Sarcoglycan full length protein - ab152676 from Abcam
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Human beta Sarcoglycan protein fragment - ab152677 from Abcam
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Human beta Sarcoglycan protein fragment - ab202169 from Abcam
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SGCB / SGC / Sarcoglycan Beta Antibody Blocking Peptide - LS-E16251 from LifeSpan Bioscience
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beta Sarcoglycan Partial Recombinant Protein - H00006443-Q01 from Novus Biologicals
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Recombinant Human beta Sarcoglycan Protein - H00006443-P01 from Novus Biologicals
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SGCB peptide - orb217926 from Biorbyt
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SGCB Blocking Peptide - 33R-3079 from Fitzgerald
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SGCB protein - 80R-4233 from Fitzgerald
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Beta-sarcoglycan Blocking Peptide - abx063257 from Abbexa
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SGCB (Beta-sarcoglycan) (87-318, His-tag) - AR51915PU-N from Acris Antibodies
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SGCB (Beta-sarcoglycan) (87-318, His-tag) - AR51915PU-S from Acris Antibodies
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SGCB (Beta-sarcoglycan) - H00006443-P01-10 from Acris Antibodies
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SGCB (Beta-sarcoglycan) - H00006443-P01-25 from Acris Antibodies
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SGCB (Beta-sarcoglycan) - H00006443-Q01-10 from Acris Antibodies
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SGCB (Beta-sarcoglycan) - H00006443-Q01-25 from Acris Antibodies
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SGCB fusion protein - ag2533 from Proteintech Group
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Recombinant Human SGCB, His-tagged - SGCB-75H from Creative Biomart
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Beta-sarcoglycan Blocking Peptide - CBP2063 from Cohesion Biosciences
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Sarcoglycan-β (V136) Peptide - BS3518P from Bioworld Technology
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Recombinant Human Beta-sarcoglycan(SGCB) - CSB-YP618082HU CSB-EP618082HU CSB-BP618082HU CSB-MP618082HU from Cusabio
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SGCB, 87-318aa, Human, His tag, E.coli - ATGP3095 from ATGen
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SGCB Protein - abx164268 from Abbexa
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SGCB (Beta-sarcoglycan) - TP304699 from Acris Antibodies
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beta Sarcoglycan Protein - NBP1-90300PEP from Novus Biologicals
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