Acot1

Gene Symbol Acot1
Entrez Gene 26897
Alt Symbol ACH2, CTE-1, CTE-I, Cte1, D12Ucla1
Species Mouse
Gene Type protein-coding
Description acyl-CoA thioesterase 1
Other Description acyl-CoA thioesterase 1, cytosolic|acyl-coenzyme A thioesterase 1|cytosolic acyl-CoA thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase
Swissprots Q549A9 O55137
Accessions AAF13870 O55137 AK053680 BC003911 AAH03911 BC022951 BC028261 AAH28261 BC040749 Y14004 CAA74327 NM_012006 NP_036136
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low activity with decanoyl-CoA as substrate. Most active on myristoyl- and palmitoyl-CoA. Introduction of one or two double bonds decreases the activity to about half. No detectable activity with bile acid CoAs such as choloyl-CoA and chenodeoxycholoyl-CoA. {ECO:0000269|PubMed:10567408}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. {ECO:0000269|PubMed:10567408, ECO:0000269|PubMed:11330065}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids

ACOT1 CRISPR/Cas9 KO Plasmid (m) - sc-424125 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 HDR Plasmid (m) - sc-424125-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 Double Nickase Plasmid (m) - sc-424125-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 Double Nickase Plasmid (m2) - sc-424125-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 CRISPR Activation Plasmid (m) - sc-424125-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 CRISPR Activation Plasmid (m2) - sc-424125-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 Lentiviral Activation Particles (m) - sc-424125-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 Lentiviral Activation Particles (m2) - sc-424125-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

ACOT1 siRNA (m) - sc-72434 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

ACOT1 shRNA Plasmid (m) - sc-72434-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

ACOT1 shRNA (m) Lentiviral Particles - sc-72434-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU214111 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN26157 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26157 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ACOT1 siRNA (Mouse) - CRM4798 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ACOT1 - MBS8219433 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Acot1 (NM_012006.2) - SHH230368 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Acot1(NM_012006.2) - SHG029863 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse ACOT1 siRNA - orb284274 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ACOT1 shRNA Plasmid (Mouse) - CHM4798 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

ACOT1 miRNA 3'UTR clone - MiUTR1M-01117 from Creative biogene

Species Reactivities Mouse
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