| Gene Symbol | Rarres2 |
|---|---|
| Entrez Gene | 71660 |
| Alt Symbol | 0610007L05Rik, AI303516 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | retinoic acid receptor responder (tazarotene induced) 2 |
| Other Description | chemerin|retinoic acid receptor responder protein 2 |
| Swissprots | Q8CHU8 Q9DD06 |
| Accessions | EDK98543 EDK98544 EDK98545 EDK98546 Q9DD06 AK002298 BAB21997 AK205386 AK217388 BC015275 BC038914 AAH38914 XM_006506623 XP_006506686 XM_006506624 XP_006506687 XM_011241467 XP_011239769 NM_027852 NP_082128 |
| Function | Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic facto |
| Subcellular Location | Secreted {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:18242188}. |
| Tissue Specificity | Expressed in the differentiated adipocytes (at protein level). Abundantly expressed in the liver, adipose tissue including visceral, epididymal, and brown adipose tissue. {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:18242188}. |