HCFC1

Gene Symbol	HCFC1
Entrez Gene	3054
Alt Symbol	CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF
Species	Human
Gene Type	protein-coding
Description	host cell factor C1
Other Description	VP16-accessory protein|host cell factor 1|protein phosphatase 1, regulatory subunit 89
Swissprots	Q6P4G5 P51610
Accessions	AAB27583 CAA55790 EAW72767 EAW72768 EAW72769 P51610 BC010606 BC019887 AAH19887 BC030560 AAH30560 BC063435 AAH63435 DQ655939 GU014839 ACX32326 L20010 XM_006724815 XP_006724878 XM_006724816 XP_006724879 XM_011531144 XP_011529446 XM_011531145 XP_011529447 XM_011531146 XP_011529448 XM_011531147 XP_011529449 XM_011531148 XP_011529450 XM_011531149 XP_011529451 XM_011531150 XP_011529452 NM_005334 NP_005325
Function	Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|Pub
Subcellular Location	Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER.
Tissue Specificity	Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269|PubMed:9389645}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HCF-1 / Host Cell Factor C1 full length protein - ab132689 from Abcam Category Protein Source Wheat germ Species Human

Human HCF-1 / Host Cell Factor C1 protein fragment - ab117018 from Abcam Category Protein Source Wheat germ Species Human

HCF1 / HCFC1 Antibody Blocking Peptide - LS-E14074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HCF1 / HCFC1 Antibody Blocking Peptide - LS-E13892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Host Cell Factor 1/HCFC1 Protein - H00003054-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Host Cell Factor 1/HCFC1 Protein - H00003054-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HCFC1 Blocking Peptide - abx062131 from Abbexa Category Peptide Species Human, Mouse, Zebrafish

Host cell factor / HCFC1 - H00003054-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Host cell factor / HCFC1 - H00003054-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Host cell factor / HCFC1 - H00003054-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Host cell factor / HCFC1 - H00003054-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HCFC1 fusion protein - ag6391 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

HCFC1 fusion protein - Ag6798 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human HCFC1 - HCFC1-29188TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human HCFC1, GST-tagged - HCFC1-13692H from Creative Biomart Category Protein Source E.coli Species Human

HCFC1 Blocking Peptide - CBP3237 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Zebrafish

Recombinant Human Host cell factor 1(HCFC1) ,partial - CSB-YP010166HU CSB-EP010166HU CSB-BP010166HU CSB-MP010166HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Host Cell Factor C1 (HCFC1) - RPC209Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Host Cell Factor C1 (HCFC1) - RPC209Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Host Cell Factor C1 (HCFC1) - RPC209Hu01 from Cloud-clone Category Protein Source E.coli Species Human

HCFC1 Peptide, Human - M34GP06871H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Host Cell Factor C1 (HCFC1) - RPU50634 from Biomatik Category Protein Prices $182.00, $315.00, $482.00, $602.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

HCFC1 Recombinant Protein (OPCD00539) - OPCD00539 from Aviva Systems Biology Category Protein Source E.coli Species Human

Host cell factor 1 (HCFC1), partial, Recombinant Protein - MBS952735 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Host Cell Factor C1, Recombinant Protein - MBS2033141 from MyBioSource Category Protein Prices $160.00, $320.00, $495.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Search more