S100a8

Gene Symbol	S100a8
Entrez Gene	20201
Alt Symbol	60B8Ag, AI323541, B8Ag, CFAg, CP-10, Caga, MRP8, p8
Species	Mouse
Gene Type	protein-coding
Description	S100 calcium binding protein A8 (calgranulin A)
Other Description	MRP-8|S100 calcium-binding protein A8|calgranulin-A|chemotactic S100 protein|chemotactic cytokine CP-10|leukocyte L1 complex light chain|migration inhibitory factor-related protein 8|pro-inflammatory S100 cytokine|protein S100-A8
Swissprots	P27005 P31724
Accessions	AAL40132 CAA61204 EDL15111 P27005 AK157837 BAE34219 AV007095 BC078629 AAH78629 M83218 AAB07229 S57123 AAB25840 Y09039 NM_013650 NP_038678
Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and
Subcellular Location	Secreted {ECO:0000269|PubMed:17767165}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Anti-MRP8 + MRP14 antibody [B314.1 (MAC 387)] - ab130234 from Abcam Prices $370.00 Sizes 500 µl Host Mouse Clonality Monoclonal Clone B314.1 (MAC 387)

S100A8 Antibody [Unconjugated] - AF3059 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Goat Clonality Polyclonal

S100A8/A9 Antibody (48M7C7) - NBP2-25256 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (335806) - MAB3059 from Novus Biologicals Prices $99.00, $259.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 335806

S100A8/A9 Antibody (48M7F9) - NBP2-25257 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 48M7F9

S100A8 Antibody (63N13G5) - NBP2-27067 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 63N13G5

S100A8/A9 Antibody (48M5F4) - NBP2-25260 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 48M5F4

S100A8/A9 Antibody (63N13G5) [Azide Free] - NBP2-25273 from Novus Biologicals Prices $339.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone 63N13G5

S100A8 Antibody [Biotin] - BAF3059 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

S100A8/A9 Antibody (48M7F9) [Azide Free] - NBP2-25270 from Novus Biologicals Prices $339.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 48M7F9

S100A8 Antibody (48M7C7) [DyLight 405LS] - NBP2-25269V3 from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8/A9 Antibody (48M7C7) [7C] - NBP2-25269V2 from Novus Biologicals Prices $319.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 405] - NBP2-25269V from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 350] - NBP2-25269UV from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 550] - NBP2-25269R from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [PE] - NBP2-25269PE from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [PerCP] - NBP2-25269PCP from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 755] - NBP2-25269IR from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [HRP] - NBP2-25269H from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 488] - NBP2-25269G from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 680] - NBP2-25269FR from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [DyLight 650] - NBP2-25269C from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [Biotin] - NBP2-25269B from Novus Biologicals Prices $299.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8 Antibody (48M7C7) [Allophycocyanin] - NBP2-25269APC from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 48M7C7

S100A8/A9 Antibody (48M5F4) [Azide Free] - NBP2-25268 from Novus Biologicals Prices $339.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 48M5F4

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