| Gene Symbol |
Slc4a4
|
| Entrez Gene |
84484
|
| Alt Symbol |
HHNMC, HNBC1, KNBC, NBC2, Nbc1, Nbc4, PNBC, SLC4A5
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 4, sodium bicarbonate cotransporter, member 4
|
| Other Description |
NBC-like protein|Na(+)/HCO3(-) cotransporter|Na+HCO3- cotransporter 4|electrogenic sodium bicarbonate cotransporter 1|sodium bicarbonate cotransporter|solute carrier family 4 (anion exchanger), member 4|solute carrier family 4 member 4|solute carrier family 4, member 4
|
| Swissprots |
Q9QXH6 O54815 O35422 Q9JI66 Q9JJ32
|
| Accessions |
EDL88532 EDL88533 EDL88534 EDL88535 Q9JI66 AF004017 AAC40034 AF027362 AAB83997 AF124441 AAF87312 AF210250 AAF21040 AF254802 AAF87553 FQ212857 XM_006250788 XP_006250850 XM_006250789 XP_006250851 XM_006250790 XP_006250852 XM_006250791 XP_006250853 NM_053424 NP_445876
|
| Function |
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10648705, ECO:0000269|PubMed:10837348, ECO:0000269|PubMed:9486238}.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000269|PubMed:9486238}; Multi-pass membrane protein {ECO:0000269|PubMed:9486238}.
|
| Tissue Specificity |
Specifically expressed in kidney and to a lower extent in liver, lung, spleen, brain, skeletal muscle and heart. In kidney, expressed in proximal tubules at the corticomedullary junction. Isoform 2 is specifically expressed in kidney. Isoform 1 is expressed in kidney and pancreas while isoform 3 is specifically expressed in brain (at protein level). In brain, isoform 1 is expressed in astrocytes while isoform 3 is expressed in neurons (at protein level). In the eye, isoform 1 is expressed in cornea, conjunctiva, lens epithelium, ciliary bodies and retina while isoform 2 is detected only in the conjunctiva. {ECO:0000269|PubMed:10648705, ECO:0000269|PubMed:10837348, ECO:0000269|PubMed:11592950, ECO:0000269|PubMed:12444017, ECO:0000269|PubMed:15329059, ECO:0000269|PubMed:9486238, ECO:0000269|PubMed:9841505}.
|
| Top Pathways |
Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion
|