| Gene Symbol | EIF3E |
|---|---|
| Entrez Gene | 534165 |
| Alt Symbol | EIF3S6 |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit E |
| Other Description | eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 48kDa |
| Swissprots | Q3T102 Q1JP76 |
| Accessions | DAA22620 Q3T102 BC102188 AAI02189 BT025478 ABF57434 NM_001034603 NP_001029775 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}. Nucleus, PML body {ECO:0000255|HAMAP-Rule:MF_03004}. |
| Top Pathways | RNA transport, Hepatitis C |
Recombinant Bovine Eukaryotic translation initiation factor 3 subunit E(EIF3E) - CSB-YP662291BO CSB-EP662291BO CSB-BP662291BO CSB-MP662291BO from Cusabio
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Eukaryotic translation initiation factor 3 subunit E (EIF3E), Recombinant Protein - MBS1471758 from MyBioSource
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