DCPS

Gene Symbol	DCPS
Entrez Gene	28960
Alt Symbol	DCS1, HINT-5, HINT5, HSL1, HSPC015
Species	Human
Gene Type	protein-coding
Description	decapping enzyme, scavenger
Other Description	decapping scavenger enzyme|heat shock-like protein 1|hint-related 7meGMP-directed hydrolase|histidine triad nucleotide-binding protein 5|histidine triad protein member 5|homolog of C. elegans 7meGMP-directed hydrolase dcs-1|m7GpppX diphosphatase|mRNA decapping enzyme|scavenger mRNA-decapping enzyme DcpS
Swissprots	Q9Y2S5 Q96C86 Q8NHL8
Accessions	EAW67691 Q96C86 AF077201 AAD26996 AF532613 AAM90310 AK026554 AK090828 AK223089 BAD96809 AK307403 AY040771 AAK91765 AY077684 AAL77216 BC014532 AAH14532 BE382749 HQ447210 ADQ31697 XM_011542778 XP_011541080 XM_011542779 XP_011541081 XM_011542780 XP_011541082 NM_014026 NP_054745
Function	Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds t
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.
Tissue Specificity	Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DcpS (G-8) - sc-271343 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DcpS (A-12) - sc-393226 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DcpS (E-20) - sc-34352 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DcpS (C-20) - sc-34355 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DcpS (H-300) - sc-368122 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DcpS (S-20) - sc-34353 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DcpS (H4-32) - sc-130451 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-DCPS antibody - ab57314 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DCPS antibody - ab126955 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-DCPS antibody - ab103589 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DCPS antibody - ab130551 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, AP) - LS-C255939 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, APC) - LS-C255940 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, Biotin) - LS-C255941 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, PE) - LS-C255944 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, FITC) - LS-C255942 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193, Azide-free, HRP) - LS-C255945 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody - LS-C310092 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa164-193) - LS-C320762 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (aa165-193) - LS-C167300 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (clone 3E5) - LS-C105135 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E5

Anti-DCPS Antibody - LS-C155445 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DCPS Antibody (clone 1G4) - LS-C133735 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G4

Anti-DCPS Antibody (clone 4H8) - LS-C174441 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H8

Anti-DCPS Antibody (clone 1E6) - LS-C174320 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E6

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